Protein Alignment CG18259 and RBM39

DIOPT Version :10

• Sequence 1: NP_573324.1
• Gene: CG18259 / 32866
• FlyBaseID: FBgn0030956
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_909122.1
• Gene: RBM39 / 9584
• HGNCID: 15923
• Length: 530
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 92/462 - (19%)
• Similarity: 157/462 - (33%)
• Gaps: 159/462 - (34%)

  Fly    37 LLNKPFFKP----SGARGSHSDTPAKRTFDARNTIAAKTRAKIADARDLINKSVRDSGIDARQLL 97
            :|..|:.|.    |.|.|....:..::...:|:....:.|:|..:     .|..||.
Human    10 MLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKE-----RKRSRDR-------- 61

  Fly    98 LERKKARSAGPILIDDEEESFEPSHRARGKGVHIGQFGHRLSMSNHADGTIQAKWDSD------- 155
             ||||::|             ....|:|.|       ..|.|.|...|...:.::.|.
Human    62 -ERKKSKS-------------RERKRSRSK-------ERRRSRSRSRDRRFRGRYRSPYSGPKFN 105

  Fly   156 ---DGVVELGNHMLSGLRRTFDPRSHKP-GKPFAPRRYIDLDNMQDLEDEEISRTLHLGQM-KQA 215
               .|.:.|.:.:....||:   ||..| .|..:|.|. .:||:  ..:|..:||:...|: .:.
Human   106 SAIRGKIGLPHSIKLSRRRS---RSKSPFRKDKSPVRE-PIDNL--TPEERDARTVFCMQLAARI 164

  Fly   216 SPRYSIGGLDLNRGDDVEMSMAPLNNKIDNNAFSIYEAARNRIERPSLTNRLVVGRSNTTKEPLE 280
            .||            |:|            ..||.....|:        .|::..|::
Human   165 RPR------------DLE------------EFFSTVGKVRD--------VRMISDRNS------- 190

  Fly   281 RRHRDTA-----STSKLPESLRSRLFVGKR---DPHISHGIYANENRRKAVGGGGARDSDSGTDS 337
            ||.:..|     ..|.:|.::.   ..|:|   .|.|.....|.:||
Human   191 RRSKGIAYVEFVDVSSVPLAIG---LTGQRVLGVPIIVQASQAEKNR------------------ 234

  Fly   338 DGDAAAPSKN-KRRSPSPLSLRTSNTKDGYRLLVSNLHTNVTTADIRELFSDIGPVYDARVV--- 398
               |||.:.| ::.|..|:           ||.|.:||.|:|...:|.:|...|.:...:::
Human   235 ---AAAMANNLQKGSAGPM-----------RLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDS 285

  Fly   399 ----RPGTAEVIYKSLEHAEKAVDTYHHRQFDDQPMHCVLVNPHSSRRSVHKASSRTVTTNSSGV 459
                ..|...:.:...|.|:||::..:..:...:||            .|...:.||..:::|..
Human   286 ETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPM------------KVGHVTERTDASSASSF 338

  Fly   460 EVDIDAL 466
             :|.|.|
Human   339 -LDSDEL 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18259	NP_573324.1	RRM_SKAR	366..434	CDD:410082	17/74 (23%)
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146		37/175 (21%)
		SF-CC1	46..518	CDD:273721	85/426 (20%)
		Interaction with JUN. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..406		14/67 (21%)
		Activating domain. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..355		14/67 (21%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250|UniProtKB:Q8VH51	355..406
		Interaction with NCOA6. /evidence=ECO:0000250|UniProtKB:Q8VH51	406..530