Protein Alignment CG18259 and POLDIP3

DIOPT Version :10

• Sequence 1: NP_573324.1
• Gene: CG18259 / 32866
• FlyBaseID: FBgn0030956
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001265586.1
• Gene: POLDIP3 / 84271
• HGNCID: 23782
• Length: 438
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 127/522 - (24%)
• Similarity: 191/522 - (36%)
• Gaps: 156/522 - (29%)

  Fly     4 DLSLDEIIERKRGQRGYRPLDRKFNANFSKPRQLLNKPFFKPSGARGSHSDTPAKRTFDARNTIA 68
            |:||||:| ||||......|:.:......:.|..:.:.....|....:.     ::.||||..|.
Human     3 DISLDELI-RKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATF-----QQRFDARQKIG 61

  Fly    69 ---AKTRAKIADARD-LINKS----VRDSGIDARQLLLERKKARSA--GPILIDDEEE--SFEPS 121
               |:.:..:.|||: |:.|.    ::....|||::|..||:..:.  .|..:.|..|  |.:.|
Human    62 LSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRS 126

  Fly   122 HRARGKGVHIGQFGHRLSMSN-----HADGTIQAKW---------DSDDGVVELGNHMLSGLRRT 172
            ..|......||.....|.::.     |.|   ...|         .....:..|..|. :|:|..
Human   127 SPAAFINPPIGTVTPALKLTKTIQRMHVD---PVGWILTTECFQVPQQKAMAPLHPHP-AGMRIN 187

  Fly   173 FDPRSHKPGKPFAPRRYIDLDNMQDLEDEEISRTLHLGQMKQASP---RYSIGGLDLNRGDDVEM 234
            . ..:|:     |.:...|||     ||::...::...|||.|:.   .:.:.||..::   :.|
Human   188 V-VNNHQ-----AKQNLYDLD-----EDDDGIASVPTKQMKFAASGGFLHHMAGLSSSK---LSM 238

  Fly   235 SMA-PLNNKIDNNAFSIYEAARNRIERPSLTNRLVVGRSNTTKEPLERRHRDTASTSKLPESLRS 298
            |.| ||...:.|:|::. .|..:.|...:|||                               .|
Human   239 SKALPLTKVVQNDAYTA-PALPSSIRTKALTN-------------------------------MS 271

  Fly   299 RLFVGKRDPHISHGIYANENRRKAVGGGGARDSDSGTDSDGDAAAPSKNKRRSP--SPLSLRTSN 361
            |..|.|.:|                                    |.:.....|  |||
Human   272 RTLVNKEEP------------------------------------PKELPAAEPVLSPL------ 294

  Fly   362 TKDGYRLLVSNLHTNVTTADIRELFSDIGPVYDARVVRPGTAEVIYKSLEHAEKAVDTYHHRQFD 426
              :|.::.|:|||..||..||.|||...|.:..||:|.||.|||::...:.|..|...|::|..|
Human   295 --EGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLD 357

  Fly   427 DQPMHCVLVNPH----------------SSRRSVHKASS--RTVTTNSSG---VEVDIDALHSVL 470
            .|||.|   |.|                |...|:.|.|.  |.|.:.||.   .|||.|.:...|
Human   358 GQPMKC---NLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTILKAL 419

  Fly   471 FR 472
            |:
Human   420 FK 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18259	NP_573324.1	RRM_SKAR	366..434	CDD:410082	29/67 (43%)
POLDIP3	NP_001265586.1	RRM_SKAR	297..365	CDD:410082	29/70 (41%)