DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18259 and Poldip3

DIOPT Version :9

Sequence 1:	NP_573324.1	Gene:	CG18259 / 32866	FlyBaseID:	FBgn0030956	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_848742.1	Gene:	Poldip3 / 73826	MGIID:	1921076	Length:	420	Species:	Mus musculus

Alignment Length:	511	Identity:	130/511 - (25%)
Similarity:	190/511 - (37%)	Gaps:	152/511 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DLSLDEIIERK----RGQRGYRPLDRKFNANFSKPRQLLNKPFFKPSGARGSHSDTPAKRTFDAR 64
            ||||||:|.::    :|:...||......:.......|:|:|      ||    ....::.||||
Mouse     3 DLSLDELIRKRGTAAKGRLSVRPGIGGVRSRVGIQHSLVNQP------AR----TATFQQRFDAR 57

  Fly    65 NTIA---AKTRAKIADARD-LINKS----VRDSGIDARQLLLERKKARSA--GPILIDDEEESFE 119
            ..|.   |:.:..:.|||: |:.|.    ::....|||::|..||:..:.  .|..:.|..|...
Mouse    58 QKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQGTVPQKPRQVADAREKIS 122

  Fly   120 PSHR--ARGKGVHIGQFGHRLSMSNHADGTIQAKWDSDDGVVELGNHMLSGLRRTFDPRSHKPGK 182
            ...|  |......||.....|.::.    |||.  .....:|.|..|. :|:|... ..:|:
Mouse   123 LKRRSPAAFTSPPIGTVTPALKLTK----TIQV--PQQKAMVPLHAHP-AGMRINV-VNNHQ--- 176

  Fly   183 PFAPRRYIDLDNMQDLEDEEISRTLHLGQMKQA---SPRYSIGGLDLNRGDDVEMSMA-PLNNKI 243
              |.:...|||     ||::|...:...|||.|   |..:.:.||..::   :.||.| ||...:
Mouse   177 --AKQNLYDLD-----EDDDIVVPVPPKQMKFAATGSLVHHMTGLSSSK---LSMSKALPLTKVV 231

  Fly   244 DNNAFSIYEAARNRIERPSLTNRLVVGRSNTTKEPLERRHRDTASTSKLPESLRSRLFVGKRDPH 308
            .|:|::          .|.|.:.:                |..|.||      .||..|.|.:|
Mouse   232 QNDAYT----------APVLPSSV----------------RTKALTS------MSRTLVNKEEP- 263

  Fly   309 ISHGIYANENRRKAVGGGGARDSDSGTDSDGDAAAPSKNKRRSP--SPLSLRTSNTKDGYRLLVS 371
                                               |.:.....|  |||        :|.::.|:
Mouse   264 -----------------------------------PKELPPAEPVLSPL--------EGTKMTVN 285

  Fly   372 NLHTNVTTADIRELFSDIGPVYDARVVRPGTAEVIYKSLEHAEKAVDTYHHRQFDDQPMHCVLVN 436
            |||..||..||.|||...|.:..||:|.||.|||::...:.|..|...|::|..|.|||.|   |
Mouse   286 NLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQPMKC---N 347

  Fly   437 PH----------------SSRRSVHKASSRTVTTNSSG----VEVDIDALHSVLFR 472
            .|                |...||.|.|......|.:.    .|||.|.:...||:
Mouse   348 LHMNGNVITSDQPILLRLSDSPSVKKESELPRRGNPASSNPPAEVDPDTVLRALFK 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18259	NP_573324.1	RRM	<345..>443	CDD:223796	37/115 (32%)
CG18259	NP_573324.1	RRM_SKAR	366..434	CDD:241125	29/67 (43%)
Poldip3	NP_848742.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..277		6/56 (11%)
		RRM_SKAR	280..348	CDD:241125	29/70 (41%)
		RRM	<284..406	CDD:223796	43/123 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..394		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839251
Domainoid	1	1.000	53	1.000	Domainoid score	I11306
eggNOG	1	0.900	-	-		E1_KOG0533
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007107
OrthoInspector	1	1.000	-	-		otm43066
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7953
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.820