DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCKLR-17D3 and CCKBR

DIOPT Version :9

Sequence 1:	NP_001097023.1	Gene:	CCKLR-17D3 / 32864	FlyBaseID:	FBgn0030954	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001350481.1	Gene:	CCKBR / 887	HGNCID:	1571	Length:	516	Species:	Homo sapiens

Alignment Length:	518	Identity:	171/518 - (33%)
Similarity:	242/518 - (46%)	Gaps:	119/518 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GTGNGGTVSLAGNATSSYGDDDRDGYMDTEPSDLVTELAFSLGTSSSPSPSSTPASSSSTSTGMP 111
            |||.|...||.           |.|      :.|:.  :.|:|..|...|....|.:......:.
Human    12 GTGPGPGASLC-----------RPG------APLLN--SSSVGNLSCEPPRIRGAGTRELELAIR 57

  Fly   112 VWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRN 176
            :.|   |::|.|.:|.||:|:|..|..:||:||:||.|||:||:||:||.|.|||.||:..|:..
Human    58 ITL---YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGT 119

  Fly   177 FIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGIL 241
            ||||..:||...:....||:||:.:||||:.|||.|||.||::|.|||.|||.::|...||...|
Human   120 FIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGL 184

  Fly   242 CMTPIAVFSQLIPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVG 306
            .|.|..|::.:.|.. |...:|...||.......:::||..||..:|.:|:.|||.||:|.||:|
Human   185 LMVPYPVYTVVQPVG-PRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLG 248

  Fly   307 MAKD-------SGRILQQ-SLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSE 363
            :..|       ..|:..| .||      ||:.|.                       ..|.|.:|
Human   249 LRFDGDSDSDSQSRVRNQGGLP------GGAGPR-----------------------EQNLGEAE 284

  Fly   364 -----GSAGGGSTNM----------------------------ATTTLTT--------------R 381
                 |.||.|.|.|                            :..:||.              |
Human   285 LWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCR 349

  Fly   382 PTAPTVITTTTTTTVTLAKTSSPSIRVHDAAL--------RRSNEAKTLESKKRVVKMLFVLVLE 438
            |....|...:....|.|.: |.|::.:  .||        .|..:||.| :|||||:||.|:|:.
Human   350 PETGAVGEDSDGCYVQLPR-SRPALEL--TALTAPGPGSGSRPTQAKLL-AKKRVVRMLLVIVVL 410

  Fly   439 FFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDT 501
            ||:||.|:|..||.....||..:..:....|||:.||:|:|:|.||:.||||:..||:|.::|
Human   411 FFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLET 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_4	120..>244	CDD:304433	63/123 (51%)
CCKLR-17D3	NP_001097023.1	7tm_1	128..487	CDD:278431	144/421 (34%)
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:333717	155/451 (34%)
		TM helix 1	57..81	CDD:320095	10/26 (38%)
		TM helix 2	90..112	CDD:320095	14/21 (67%)
		TM helix 3	128..150	CDD:320095	9/21 (43%)
		TM helix 4	173..189	CDD:320095	5/15 (33%)
		TM helix 5	216..239	CDD:320095	8/22 (36%)
		TM helix 6	398..423	CDD:320095	14/24 (58%)
		TM helix 7	438..463	CDD:320095	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147359
Domainoid	1	1.000	227	1.000	Domainoid score	I2509
eggNOG	1	0.900	-	-		E33208_3BDYY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3167
Isobase	1	0.950	-	0	Normalized mean entropy	S5836
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1042780at2759
OrthoFinder	1	1.000	-	-		FOG0001992
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105354
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1306
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.610