Protein Alignment CCKLR-17D3 and QRFPR

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 91/391 - (23%)
• Similarity: 160/391 - (40%)
• Gaps: 117/391 - (29%)

  Fly   120 MILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLC 184
            :|...|:.||.||...:.:::.|||:||:|:.:||:||:|:...|:|||::..:..|::.|.|:|
Human    54 LIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFIC 118

  Fly   185 KLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQ-TISHAYKIIGFIWLGGILCMTPIAV 248
            |:..|.|:.:|.....|:..|:.||:..:.||.:.: || |...|:.::|.:||..::..:|:..
Human   119 KMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMK-WQYTNRRAFTMLGVVWLVAVIVGSPMWH 182

  Fly   249 FSQL-----IPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMA 308
            ..||     ....:...| |.|.|....::..|...:..:|.:|||:|:.:.|..|...|::...
Human   183 VQQLEIKYDFLYEKEHIC-CLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKR 246

  Fly   309 KDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNM 373
            ...|.:|:
Human   247 VGDGSVLR--------------------------------------------------------- 254

  Fly   374 ATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLE 438
                                             .:|...:     :|....|||.|.|:..:|..
Human   255 ---------------------------------TIHGKEM-----SKIARKKKRAVIMMVTVVAL 281

  Fly   439 FFICWTPLYVINTMVMLIGPVVY-----EYVDYT---AISFLQLLAYSSSCCNPITYCFMNASFR 495
            |.:||.|.:|::.|      :.|     ||.|.|   ..:.:|::.:|:|.||||.|.|||.:|:
Human   282 FAVCWAPFHVVHMM------IEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFK 340

  Fly   496 R 496
            :
Human   341 K 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	91/391 (23%)
		TM helix 1	114..138	CDD:320334	6/17 (35%)
		TM helix 2	147..169	CDD:320334	10/21 (48%)
		TM helix 3	185..207	CDD:320334	6/21 (29%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	6/22 (27%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	10/27 (37%)
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	91/391 (23%)
		TM helix 1	47..73	CDD:320333	6/18 (33%)
		TM helix 2	80..106	CDD:320333	12/25 (48%)
		TM helix 3	118..148	CDD:320333	9/29 (31%)
		TM helix 4	161..182	CDD:320333	5/20 (25%)
		TM helix 5	211..236	CDD:320333	7/24 (29%)
		TM helix 6	266..296	CDD:320333	12/35 (34%)
		TM helix 7	311..336	CDD:320333	9/24 (38%)