Protein Alignment CCKLR-17D3 and TACR2

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001048.2
• Gene: TACR2 / 6865
• HGNCID: 11527
• Length: 398
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 109/440 - (24%)
• Similarity: 172/440 - (39%)
• Gaps: 128/440 - (29%)

  Fly    79 DLVTELAFSLGTSSSPSPSSTPASSSSTSTGMPVWLI----PSYSMILLFAVLGNLLVISTLVQN 139
            |:|||...|.|..|:        ::..|:..||.|.:    .:|..::|.||.||.:||..::.:
Human     5 DIVTEANISSGPESN--------TTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAH 61

  Fly   140 RRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVA 204
            |||||:||.|::|||::|:.:.........|......:.||...|.........::.||.:::.|
Human    62 RRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTA 126

  Fly   205 ISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPGYCKCREFWP- 268
            |:.:||.||.||.:.|.....:.|  :|..|||..:...:|...:|.:  |...|..||...||
Human   127 IAADRYMAIVHPFQPRLSAPSTKA--VIAGIWLVALALASPQCFYSTV--TMDQGATKCVVAWPE 187

  Fly   269 DQGYE--LFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAP 331
            |.|.:  |.|::::..|:..|||.|:.|||.:|..||:
Human   188 DSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLW--------------------------- 225

  Fly   332 NPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTV 396
                                                                             
Human   226 ----------------------------------------------------------------- 225

  Fly   397 TLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVY 461
               :.:.|..:.|.|.||.      |::.|:.||.:.::||.|.|||.|.:    :..::|....
Human   226 ---RRAVPGHQAHGANLRH------LQAMKKFVKTMVLVVLTFAICWLPYH----LYFILGSFQE 277

  Fly   462 EYVDYTAISFLQL----LAYSSSCCNPITYCFMNASFRRAFVDTFKGLPW 507
            :...:..|..:.|    ||.||:..|||.||.:|..||..|...|:..||
Human   278 DIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPW 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	95/396 (24%)
		TM helix 1	114..138	CDD:320334	8/27 (30%)
		TM helix 2	147..169	CDD:320334	6/21 (29%)
		TM helix 3	185..207	CDD:320334	4/21 (19%)
		TM helix 4	230..246	CDD:320334	4/15 (27%)
		TM helix 5	274..297	CDD:320334	9/22 (41%)
		TM helix 6	429..451	CDD:320334	9/21 (43%)
		TM helix 7	466..491	CDD:320334	11/28 (39%)
TACR2	NP_001048.2	7tmA_SKR_NK2R	34..318	CDD:320670	94/392 (24%)
		TM helix 1	35..61	CDD:320670	8/25 (32%)
		TM helix 2	68..94	CDD:320670	8/25 (32%)
		TM helix 3	106..136	CDD:320670	8/29 (28%)
		TM helix 4	147..168	CDD:320670	6/22 (27%)
		TM helix 5	194..223	CDD:320670	11/28 (39%)
		TM helix 6	243..273	CDD:320670	10/33 (30%)
		TM helix 7	286..311	CDD:320670	10/24 (42%)