Protein Alignment CCKLR-17D3 and BRS3

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001718.1
• Gene: BRS3 / 680
• HGNCID: 1113
• Length: 399
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 97/437 - (22%)
• Similarity: 171/437 - (39%)
• Gaps: 135/437 - (30%)

  Fly    88 LGTSSSPSPSSTPASSSSTSTGMPVW-------------LIPSYSMILLFAVLGNLLVISTLVQN 139
            :..::....||:..|:.:|:.|   |             :..:|::|:...:|||.::|....:.
Human    14 ISITNDTESSSSVVSNDNTNKG---WSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKT 75

  Fly   140 RRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVA 204
            :.|:|:.|:|:.:||..|:||.:.|:||.....|...::||...||:..|.:..||.||.:||..
Human    76 KSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTI 140

  Fly   205 ISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLI----PTSRPGYCKCRE 265
            :|.:||.|:..||..:....|.......|.:|:..::...|.|:||.:.    |.....:..|..
Human   141 LSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTS 205

  Fly   266 FWPDQGYELFYNILLDFLLL-VLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGS 329
            :...:......:.||.||:. ::||.::.|.|.||.||||
Human   206 YPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLY------------------------- 245

  Fly   330 APNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTT 394
                                                       .:|..:.|.
Human   246 -------------------------------------------KSTLNIPTE------------- 254

  Fly   395 TVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTP---LYVINTMVMLI 456
                               .:|:..|.:||:||:.:.:.|||..|.:||.|   ||:.::...
Human   255 -------------------EQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTS-- 298

  Fly   457 GPVVYEYVDYTAISFL-----QLLAYSSSCCNPITYCFMNASFRRAF 498
                ..|||.:|:.|:     ::||:|:||.||....:::.||::.|
Human   299 ----QTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHF 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	91/411 (22%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	10/21 (48%)
		TM helix 3	185..207	CDD:320334	8/21 (38%)
		TM helix 4	230..246	CDD:320334	2/15 (13%)
		TM helix 5	274..297	CDD:320334	7/23 (30%)
		TM helix 6	429..451	CDD:320334	9/24 (38%)
		TM helix 7	466..491	CDD:320334	9/29 (31%)
BRS3	NP_001718.1	7tmA_BRS-3	48..341	CDD:320251	90/398 (23%)
		TM helix 1	49..75	CDD:320251	6/25 (24%)
		TM helix 2	82..108	CDD:320251	10/25 (40%)
		TM helix 3	120..150	CDD:320251	13/29 (45%)
		TM helix 4	162..182	CDD:320251	2/19 (11%)
		TM helix 5	214..239	CDD:320251	8/24 (33%)
		TM helix 6	264..294	CDD:320251	13/29 (45%)
		TM helix 7	309..334	CDD:320251	8/24 (33%)