Protein Alignment CCKLR-17D3 and SSTR5

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001044.1
• Gene: SSTR5 / 6755
• HGNCID: 11334
• Length: 364
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 111/472 - (23%)
• Similarity: 182/472 - (38%)
• Gaps: 147/472 - (31%)

  Fly    96 PSSTPASSSST------------------STGMPVWLIPSYSMILLFAVL-GNLLVISTLVQNRR 141
            |:|||:.::|:                  |.|....|:|...:::..|.| ||.|||..:::..:
Human     6 PASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAK 70

  Fly   142 MRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAIS 206
            |:|:||:::||||::|:|. :|.:|..........:.||..||:|.......:...|.:.|..:|
Human    71 MKTVTNIYILNLAVADVLY-MLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMS 134

  Fly   207 CERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMT-PIAVFSQLIPTSRPGYCKCREFWPDQ 270
            .:||.|:.|||.|..|:....|.......|:.. |||: |:.||:.:   ...|.|...  ||:.
Human   135 VDRYLAVVHPLSSARWRRPRVAKLASAAAWVLS-LCMSLPLLVFADV---QEGGTCNAS--WPEP 193

  Fly   271 -----GYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSA 330
                 ...:.|..:|.|.   .||||:|:.|:||
Human   194 VGLWGAVFIIYTAVLGFF---APLLVICLCYLLI------------------------------- 224

  Fly   331 PNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTT 395
                                                                             
Human   225 ----------------------------------------------------------------- 224

  Fly   396 VTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVV 460
              :.|..:..:||  ..:||       .|:::|.:|:.|:||.|..||.|.:.:| :|.|...:.
Human   225 --VVKVRAAGVRV--GCVRR-------RSERKVTRMVLVVVLVFAGCWLPFFTVN-IVNLAVALP 277

  Fly   461 YEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRRGAGASGGVGGAAGGGL 525
            .|........|:.:|:|::||.||:.|.|::.:||::|.   |.|..|:|:||............
Human   278 QEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQ---KVLCLRKGSGAKDADATEPRPDR 339

  Fly   526 SASQAGAGPGAY-ASAN 541
            ...|..|.|.|: |:||
Human   340 IRQQQEATPPAHRAAAN 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	90/392 (23%)
		TM helix 1	114..138	CDD:320334	9/24 (38%)
		TM helix 2	147..169	CDD:320334	9/21 (43%)
		TM helix 3	185..207	CDD:320334	3/21 (14%)
		TM helix 4	230..246	CDD:320334	4/16 (25%)
		TM helix 5	274..297	CDD:320334	8/22 (36%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	9/24 (38%)
SSTR5	NP_001044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		5/13 (38%)
		7tmA_SSTR5	51..315	CDD:320640	88/381 (23%)
		TM helix 2	75..101	CDD:320640	10/26 (38%)
		TM helix 3	112..142	CDD:320640	8/29 (28%)
		TM helix 4	154..176	CDD:320640	6/22 (27%)
		TM helix 5	198..227	CDD:320640	11/129 (9%)
		TM helix 6	241..271	CDD:320640	11/30 (37%)
		TM helix 7	283..308	CDD:320640	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..364		8/30 (27%)