Protein Alignment CCKLR-17D3 and prlhr2a

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001034615.1
• Gene: prlhr2a / 654782
• ZFINID: ZDB-GENE-060209-1
• Length: 370
• Species: Danio rerio
• Alignment Length: 414
• Identity: 106/414 - (25%)
• Similarity: 162/414 - (39%)
• Gaps: 120/414 - (28%)

  Fly   114 LIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTL-LRNF 177
            :||.|::::|..|.||.|::..:.|.::|..:||.|:.|||.||||:...|:|.||.... .|.:
Zfish    61 IIPCYALVVLVGVFGNYLLLYVICQTKKMHNVTNFFIGNLAFSDMLMCATCVPFTLAYAFNPRGW 125

  Fly   178 IFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILC 242
            :||.|:|.|....|..:|.||.:||.||..:||||..|||:.|. ..::..|.:.| ||:.....
Zfish   126 VFGRFMCYLVFLIQPVTVYVSVFTLTAIGVDRYYATVHPLKKRI-SVLACTYLLSG-IWILSCGL 188

  Fly   243 MTPIAVFSQLIPTSRPGYCKCREFWPDQGYE-LFYNILLDFLLLVLPLLVLCVAYILITRTLYVG 306
            :.|....:..:.....|:..|.|||..|..| |.|.....|:..||||..||::|:.|:..|
Zfish   189 VAPAVAHTYHVEFKDEGFTICEEFWMGQEKERLAYAYSTLFITYVLPLSALCISYLCISVKL--- 250

  Fly   307 MAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGST 371
                                            .||::
Zfish   251 --------------------------------RNCVV---------------------------- 255

  Fly   372 NMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLV 436
                                            |..|....|     ||:... |::..:::.::|
Zfish   256 --------------------------------PGHRTQSQA-----EAQRAR-KRKTFRLVSLVV 282

  Fly   437 LEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLLAY----SSSCCNPITYCFMNASFRRA 497
            ..|.|||.|:.|.|    ::..:..:.:|......:|||.:    |||||||..|.:::..||..
Zfish   283 AAFGICWLPISVFN----VLRDIDIDLIDKRYFLLIQLLCHLCGMSSSCCNPFLYAWLHDRFRAE 343

  Fly   498 FVDTFK-------GLPWRRGAGAS 514
            ....|.       |:|....|.||
Zfish   344 LRKMFTCHRRIGIGIPANNCATAS 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	100/389 (26%)
		TM helix 1	114..138	CDD:320334	8/23 (35%)
		TM helix 2	147..169	CDD:320334	11/21 (52%)
		TM helix 3	185..207	CDD:320334	9/21 (43%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	9/22 (41%)
		TM helix 6	429..451	CDD:320334	7/21 (33%)
		TM helix 7	466..491	CDD:320334	11/28 (39%)
prlhr2a	NP_001034615.1	7tmA_PrRP_R	59..344	CDD:320516	100/389 (26%)
		TM helix 1	60..86	CDD:320516	8/24 (33%)
		TM helix 2	93..118	CDD:320516	14/24 (58%)
		TM helix 3	132..162	CDD:320516	14/29 (48%)
		TM helix 4	173..194	CDD:320516	5/21 (24%)
		TM helix 5	220..249	CDD:320516	11/28 (39%)
		TM helix 6	269..299	CDD:320516	9/34 (26%)
		TM helix 7	312..337	CDD:320516	11/24 (46%)