Protein Alignment CCKLR-17D3 and NPFFR1

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_071429.1
• Gene: NPFFR1 / 64106
• HGNCID: 17425
• Length: 430
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 137/508 - (26%)
• Similarity: 195/508 - (38%)
• Gaps: 153/508 - (30%)

  Fly    89 GTSSSPSPSSTPASSSSTST----------------GMPV--WLIPSYSMILLFAVLGNLLVIST 135
            |..|.|..||.|.|.:.|:|                ..||  ..|.:|::|.|..::||.||...
Human     3 GEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFI 67

  Fly   136 LVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSW 200
            :::||.|.|:||:|:||||:||:|:|:.|||.|||..|:..:.|....||:....|..||:.|.:
Human    68 VLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVF 132

  Fly   201 TLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPT---------- 255
            |||||:.||:..|.||.|.:  .|:..|...|..||...:|.|.|.||  .|..|
Human   133 TLVAIAVERFRCIVHPFREK--LTLRKALVTIAVIWALALLIMCPSAV--TLTVTREEHHFMVDA 193

  Fly   256 ---SRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQ 317
               |.|.| .|.|.||::|....|..:|...:.:.||.::.|.|..|.|.|.
Human   194 RNRSYPLY-SCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLC------------- 244

  Fly   318 SLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRP 382
                       .||.|                                |.||.
Human   245 -----------QAPGP--------------------------------APGGE------------ 254

  Fly   383 TAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLY 447
                             :.:.|.     |:.||:          |||.||.::.|.|.:.|.||:
Human   255 -----------------EAADPR-----ASRRRA----------RVVHMLVMVALFFTLSWLPLW 287

  Fly   448 VINTMV---MLIGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRR 509
            .:..::   .|..|.::....| |..|...||:.:|..|||.|.:.|.:|||.|...|:.....|
Human   288 ALLLLIDYGQLSAPQLHLVTVY-AFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPR 351

  Fly   510 GAGASGGVGGAAGGGL-------------SASQAGAGPGAYASANTNISLNPG 549
            .:|:.........|||             |...:.:||.:.|.....:.|..|
Human   352 PSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNG 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	114/403 (28%)
		TM helix 1	114..138	CDD:320334	8/23 (35%)
		TM helix 2	147..169	CDD:320334	13/21 (62%)
		TM helix 3	185..207	CDD:320334	10/21 (48%)
		TM helix 4	230..246	CDD:320334	5/15 (33%)
		TM helix 5	274..297	CDD:320334	5/22 (23%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	10/24 (42%)
NPFFR1	NP_071429.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		7/16 (44%)
		7tm_GPCRs	44..340	CDD:475119	113/401 (28%)
		TM helix 1	46..70	CDD:410628	8/23 (35%)
		TM helix 2	79..101	CDD:410628	13/21 (62%)
		TM helix 3	117..139	CDD:410628	10/21 (48%)
		TM helix 4	160..176	CDD:410628	5/15 (33%)
		TM helix 5	214..237	CDD:410628	5/22 (23%)
		TM helix 6	269..291	CDD:410628	8/21 (38%)
		TM helix 7	308..333	CDD:410628	10/25 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..413		6/26 (23%)