Protein Alignment CCKLR-17D3 and cckar

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_697493.2
• Gene: cckar / 569038
• ZFINID: ZDB-GENE-120404-2
• Length: 446
• Species: Danio rerio
• Alignment Length: 469
• Identity: 162/469 - (34%)
• Similarity: 226/469 - (48%)
• Gaps: 92/469 - (19%)

  Fly    88 LGTSSSPSPSSTPASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLN 152
            :|..|.....|||:.|........|.:: .|::|.:.:.|||.|:|:.|::||||||:||:|||:
Zfish    25 IGNLSECKNESTPSPSEPKDMNQTVRIV-LYALIFILSFLGNSLIIAVLLRNRRMRTVTNLFLLS 88

  Fly   153 LAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPL 217
            ||:||::|.|.|||.||:..|:::||||..:||:..:....||:||:..|||||.|||.|||:||
Zfish    89 LAVSDLMLCVFCMPFTLIPNLMKDFIFGSGMCKVATYFMGISVSVSTLNLVAISLERYSAICNPL 153

  Fly   218 RSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPGYC---KCREFWPDQGYELFYNIL 279
            :||:|||.|||.|:|...|:...|.|.|..:.|.|:|..|....   .||..||....:.:|..|
Zfish   154 KSRAWQTKSHAVKVISATWVVSFLLMLPYPIGSTLVPFIRSNNSTGNMCRLVWPSDVMQTWYIFL 218

  Fly   280 LDFLLLVLPLLVLCVAYILITRTLYVGMA-----KDSGRILQQSLPVSATTAGGSAPNPGTSSSS 339
            |..|.|| |.:::..||.|.:..||.|:.     :.|.|..:.                ||||.
Zfish   219 LLTLFLV-PGIIMMTAYGLTSLELYRGIRFEMTNRKSNREKEY----------------GTSSL- 265

  Fly   340 NCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSP 404
                              .||:|:|.....|..                           |.|.|
Zfish   266 ------------------KNGDSDGCYFQPSKK---------------------------KRSEP 285

  Fly   405 SIRVH-DAALRR---SNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVD 465
            .:..| .:.|||   ::....|.:||||::||.|:|..||:||||::|:|.............:.
Zfish   286 VMPSHPKSKLRRVCSNSPTANLMAKKRVIRMLLVIVGLFFLCWTPVFVVNAWRAFDRRSADSLLS 350

  Fly   466 YTAISFLQLLAYSSSCCNPITYCFMNASFR----------RAFVDTFKGLPWRRGAGASGGVG-- 518
            ...|||:.||:|:|:|.|||.|||||..||          |..||.|.....||.|..:||:|
Zfish   351 GAPISFIHLLSYTSACVNPIVYCFMNKRFRQGILSTFSCCRGDVDEFSRSSTRRSARGAGGLGTL 415

  Fly   519 ----GAAGGGLSAS 528
                |...|....|
Zfish   416 FKGAGQTDGNTQTS 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	144/407 (35%)
		TM helix 1	114..138	CDD:320334	8/23 (35%)
		TM helix 2	147..169	CDD:320334	13/21 (62%)
		TM helix 3	185..207	CDD:320334	9/21 (43%)
		TM helix 4	230..246	CDD:320334	5/15 (33%)
		TM helix 5	274..297	CDD:320334	8/22 (36%)
		TM helix 6	429..451	CDD:320334	11/21 (52%)
		TM helix 7	466..491	CDD:320334	14/24 (58%)
cckar	XP_697493.2	7tmA_CCK-AR	48..383	CDD:320644	143/398 (36%)
		TM helix 1	49..75	CDD:320644	9/26 (35%)
		TM helix 2	82..108	CDD:320644	16/25 (64%)
		TM helix 3	120..150	CDD:320644	15/29 (52%)
		TM helix 4	163..184	CDD:320644	8/20 (40%)
		TM helix 5	212..240	CDD:320644	10/28 (36%)
		TM helix 6	308..338	CDD:320644	16/29 (55%)
		TM helix 7	351..376	CDD:320644	14/24 (58%)