Protein Alignment CCKLR-17D3 and OPRL1

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 97/428 - (22%)
• Similarity: 163/428 - (38%)
• Gaps: 145/428 - (33%)

  Fly    93 SPSPSSTP-------ASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFL 150
            ||:.|..|       :..:....|:.|.::..|..:.:..:|||.||:..::::.:|:|.||:::
Human    26 SPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYI 90

  Fly   151 LNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICH 215
            .|||::|.|: :|.:|......||..:.||..|||........::..|::||.|:|.:||.||||
Human    91 FNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICH 154

  Fly   216 PLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQL------------IPTSRPGYCKCREFWP 268
            |:|:...:|.|.|..:...||....:...|:|:....            |||.       :::|.
Human   155 PIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTP-------QDYWG 212

  Fly   269 DQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNP 333
            .     .:.|.:.....::|:||:.|.|.|:.|.|. |:     |:|..|
Human   213 P-----VFAICIFLFSFIVPVLVISVCYSLMIRRLR-GV-----RLLSGS--------------- 251

  Fly   334 GTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTL 398
                                                                             
Human   252 ----------------------------------------------------------------- 251

  Fly   399 AKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEY 463
                    |..|..||            |:.:::.|:|..|..||||:.|   .|:..|..|...
Human   252 --------REKDRNLR------------RITRLVLVVVAVFVGCWTPVQV---FVLAQGLGVQPS 293

  Fly   464 VDYTAISFLQL---LAYSSSCCNPITYCFMNASFRRAF 498
            .: ||::.|:.   |.|.:||.|||.|.|::.:|:..|
Human   294 SE-TAVAILRFCTALGYVNSCLNPILYAFLDENFKACF 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	91/400 (23%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	8/21 (38%)
		TM helix 3	185..207	CDD:320334	5/21 (24%)
		TM helix 4	230..246	CDD:320334	2/15 (13%)
		TM helix 5	274..297	CDD:320334	5/22 (23%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	12/27 (44%)
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	91/400 (23%)
		TM helix 1	53..79	CDD:320220	6/25 (24%)
		TM helix 2	86..112	CDD:320220	9/26 (35%)
		TM helix 3	123..153	CDD:320220	10/29 (34%)
		TM helix 4	165..187	CDD:320220	5/21 (24%)
		TM helix 5	212..241	CDD:320220	7/33 (21%)
		TM helix 6	256..286	CDD:320220	12/44 (27%)
		TM helix 7	298..323	CDD:320220	10/24 (42%)