Protein Alignment CCKLR-17D3 and OPRD1

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_000902.3
• Gene: OPRD1 / 4985
• HGNCID: 8153
• Length: 372
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 102/467 - (21%)
• Similarity: 177/467 - (37%)
• Gaps: 140/467 - (29%)

  Fly    91 SSSPSPSSTPASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAI 155
            |:..:.|..|.:.|::|..:.:.:...||.:....:|||:||:..:|:..:|:|.||:::.|||:
Human    29 SAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLAL 93

  Fly   156 SDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSR 220
            :| .|....:|......|:..:.|||.|||........::..|.:||..:|.:||.|:|||:::.
Human    94 AD-ALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKAL 157

  Fly   221 SWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPGYCKCREFWPDQG--YELFYNILLDFL 283
            .::|.:.|..|...||:.......||.|.:...|  |.|...|...:|...  ::....|.:...
Human   158 DFRTPAKAKLINICIWVLASGVGVPIMVMAVTRP--RDGAVVCMLQFPSPSWYWDTVTKICVFLF 220

  Fly   284 LLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTAT 348
            ..|:|:|::.|.|.|:...|      .|.|:|
Human   221 AFVVPILIITVCYGLMLLRL------RSVRLL--------------------------------- 246

  Fly   349 AVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAAL 413
                      :|:.|                                             .|.:|
Human   247 ----------SGSKE---------------------------------------------KDRSL 256

  Fly   414 RRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVD--------YTAIS 470
            |            |:.:|:.|:|..|.:||.|:::.        .:|:..||        ..|:.
Human   257 R------------RITRMVLVVVGAFVVCWAPIHIF--------VIVWTLVDIDRRDPLVVAALH 301

  Fly   471 FLQLLAYSSSCCNPITYCFMNASFRRAFVDTFK---GLP----WRRGAGASGGVGGAAGGGLSAS 528
            ....|.|::|..||:.|.|::.:|:|.|....:   |.|    :.|...|:      |...::|.
Human   302 LCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREAT------ARERVTAC 360

  Fly   529 QAGAGPGAYASA 540
            ....|||..|:|
Human   361 TPSDGPGGGAAA 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	85/395 (22%)
		TM helix 1	114..138	CDD:320334	7/23 (30%)
		TM helix 2	147..169	CDD:320334	7/21 (33%)
		TM helix 3	185..207	CDD:320334	4/21 (19%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	5/22 (23%)
		TM helix 6	429..451	CDD:320334	7/21 (33%)
		TM helix 7	466..491	CDD:320334	8/24 (33%)
OPRD1	NP_000902.3	7tmA_Delta_opioid_R	50..329	CDD:320217	85/395 (22%)
		TM helix 1	51..77	CDD:320217	8/25 (32%)
		TM helix 2	84..110	CDD:320217	8/26 (31%)
		TM helix 3	121..151	CDD:320217	9/29 (31%)
		TM helix 4	163..185	CDD:320217	6/21 (29%)
		TM helix 5	209..239	CDD:320217	7/29 (24%)
		TM helix 6	258..284	CDD:320217	8/33 (24%)
		TM helix 7	297..322	CDD:320217	8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..372		9/37 (24%)