Protein Alignment CCKLR-17D3 and NPY1R

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_000900.1
• Gene: NPY1R / 4886
• HGNCID: 7956
• Length: 384
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 99/401 - (24%)
• Similarity: 163/401 - (40%)
• Gaps: 138/401 - (34%)

  Fly   117 SYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGE 181
            :|..:::..|.|||.:|..:::.:.||.:||:.::||:.||:|:.::|:|.|.|.||:.:::|||
Human    46 AYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGE 110

  Fly   182 FLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTIS-HAYKIIGFIWLGGILCMTP 245
            .:|||..|.|..|:.||.::||.|:.||:..|.:|   |.|:..: |||..|..||:..:....|
Human   111 AMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVIWVLAVASSLP 172

  Fly   246 IAVFSQLIPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYV---GM 307
            ..::.  :.|..|                |.|:.||             ||    :..||   ..
Human   173 FLIYQ--VMTDEP----------------FQNVTLD-------------AY----KDKYVCFDQF 202

  Fly   308 AKDSGR--------ILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEG 364
            ..||.|        :||...|:                   |.:.:....:|......||...:
Human   203 PSDSHRLSYTTLLLVLQYFGPL-------------------CFIFICYFKIYIRLKRRNNMMDK- 247

  Fly   365 SAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVV 429
                                                             .|.|:.::.|: ||:.
Human   248 -------------------------------------------------MRDNKYRSSET-KRIN 262

  Fly   430 KMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAIS-------FL--QLLAYSSSCCNPI 485
            .||..:|:.|.:||.||.:.||        |::: ::..|:       ||  .|.|..|:|.|||
Human   263 IMLLSIVVAFAVCWLPLTIFNT--------VFDW-NHQIIATCNHNLLFLLCHLTAMISTCVNPI 318

  Fly   486 TYCFMNASFRR 496
            .|.|:|.:|:|
Human   319 FYGFLNKNFQR 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	99/401 (25%)
		TM helix 1	114..138	CDD:320334	6/20 (30%)
		TM helix 2	147..169	CDD:320334	8/21 (38%)
		TM helix 3	185..207	CDD:320334	10/21 (48%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	5/22 (23%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	12/33 (36%)
NPY1R	NP_000900.1	7tmA_NPY1R	41..331	CDD:320517	99/401 (25%)
		TM helix 1	42..68	CDD:320517	6/21 (29%)
		TM helix 2	75..100	CDD:320517	10/24 (42%)
		TM helix 3	113..143	CDD:320517	13/29 (45%)
		TM helix 4	154..175	CDD:320517	7/20 (35%)
		TM helix 5	208..237	CDD:320517	6/47 (13%)
		TM helix 6	256..286	CDD:320517	13/38 (34%)
		TM helix 7	299..324	CDD:320517	11/24 (46%)