DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCKLR-17D3 and Hcrtr2

DIOPT Version :10

Sequence 1:NP_001097023.1 Gene:CCKLR-17D3 / 32864 FlyBaseID:FBgn0030954 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_945200.1 Gene:Hcrtr2 / 387285 MGIID:2680765 Length:460 Species:Mus musculus


Alignment Length:416 Identity:111/416 - (26%)
Similarity:181/416 - (43%) Gaps:98/416 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 W-LIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRN 176
            | ||..|.::.:.|::||:||...:.:|..|||:||.|::||:::|:|:.:.|:|.|||..:...
Mouse    55 WVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITET 119

  Fly   177 FIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGIL 241
            :.||:.|||:..:.|..||:||..||..|:.:|:|||||||..:|  |...|...|..||:...:
Mouse   120 WFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARNSIVVIWIVSCI 182

  Fly   242 CMTPIAVF---SQLIP---TSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILIT 300
            .|.|.|:.   |.::|   .....:..|.|.|..:.|...|:|....:..:.||.::.:||:.|.
Mouse   183 IMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMILAYLQIF 247

  Fly   301 RTLYVGMAKDSGRILQ----QSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGN 361
            |.|:......:..::|    |..|||.                                      
Mouse   248 RKLWCRQIPGTSSVVQRKWKQQQPVSQ-------------------------------------- 274

  Fly   362 SEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKK 426
               ..|.|..:.|                                |:...|.    |.|.:.:::
Mouse   275 ---PRGSGQQSKA--------------------------------RISAVAA----EIKQIRARR 300

  Fly   427 RVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVY----EYVDYTAISFLQLLAYSSSCCNPITY 487
            :..:||.|::|.|.||:.|:.::|.:..:.|...:    |.| |...:|...|.|::|..|||.|
Mouse   301 KTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETV-YAWFTFSHWLVYANSAANPIIY 364

  Fly   488 CFMNASFRRAFVDTFK---GLPWRRG 510
            .|::..||..|...|.   |:..|:|
Mouse   365 NFLSGKFREEFKAAFSCCLGVHHRQG 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCKLR-17D3NP_001097023.1 7tm_GPCRs 112..498 CDD:475119 106/399 (27%)
TM helix 1 114..138 CDD:320334 8/23 (35%)
TM helix 2 147..169 CDD:320334 8/21 (38%)
TM helix 3 185..207 CDD:320334 9/21 (43%)
TM helix 4 230..246 CDD:320334 4/15 (27%)
TM helix 5 274..297 CDD:320334 5/22 (23%)
TM helix 6 429..451 CDD:320334 8/21 (38%)
TM helix 7 466..491 CDD:320334 10/24 (42%)
Hcrtr2NP_945200.1 Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614 33..49
7tmA_OXR 55..375 CDD:320336 106/399 (27%)
TM helix 1 56..82 CDD:320336 8/25 (32%)
TM helix 2 89..115 CDD:320336 12/25 (48%)
TM helix 3 127..157 CDD:320336 13/29 (45%)
TM helix 4 168..189 CDD:320336 6/20 (30%)
TM helix 5 220..249 CDD:320336 7/28 (25%)
TM helix 6 297..327 CDD:320336 9/29 (31%)
TM helix 7 343..368 CDD:320336 10/24 (42%)
Orexin_rec2 386..443 CDD:427531 2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

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