Protein Alignment CCKLR-17D3 and Oprk1

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_038965287.1
• Gene: Oprk1 / 29335
• RGDID: 69426
• Length: 431
• Species: Rattus norvegicus
• Alignment Length: 454
• Identity: 102/454 - (22%)
• Similarity: 171/454 - (37%)
• Gaps: 150/454 - (33%)

  Fly    76 EPSDLVTELAFSLGTSSSPSPSSTPASSSST-------------STGMPVWLIPSYSMILLFAVL 127
            ||.......|..|..|||..|:...:.|:.:             |..:||.:...||::.:..::
  Rat    62 EPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLV 126

  Fly   128 GNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQA 192
            ||.||:..:::..:|:|.||:::.|||::|.|: ...||......|:.::.||:.|||:......
  Rat   127 GNSLVMFVIIRYTKMKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDY 190

  Fly   193 ASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGF-IW------------LGGILCMT 244
            .::..|.:||..:|.:||.|:|||:::..::|...| |||.. ||            |||.....
  Rat   191 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKA-KIINICIWLLASSVGISAIVLGGTKVRE 254

  Fly   245 PIAVFSQLIPTSRPGYCKCREFWPDQGY---ELFYNILLDFLLLVLPLLVLCVAYILITRTLYVG 306
            .:.|.            :|...:||..|   :||..|.:.....|:|:|::.|.|.|:...|
  Rat   255 DVDVI------------ECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRL--- 304

  Fly   307 MAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGST 371
               .|.|:|..|
  Rat   305 ---KSVRLLSGS----------------------------------------------------- 313

  Fly   372 NMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLV 436
                                               |..|..||            |:.|::.|:|
  Rat   314 -----------------------------------REKDRNLR------------RITKLVLVVV 331

  Fly   437 LEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVD 500
            ..|.|||||:::. .:|..:|...:.....::..|...|.|::|..||:.|.|::.:|:|.|.|
  Rat   332 AVFIICWTPIHIF-ILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRD 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	89/401 (22%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	8/21 (38%)
		TM helix 3	185..207	CDD:320334	4/21 (19%)
		TM helix 4	230..246	CDD:320334	8/28 (29%)
		TM helix 5	274..297	CDD:320334	7/22 (32%)
		TM helix 6	429..451	CDD:320334	9/21 (43%)
		TM helix 7	466..491	CDD:320334	8/24 (33%)
Oprk1	XP_038965287.1	7tmA_Kappa_opioid_R	111..392	CDD:320219	89/401 (22%)
		TM helix 1	112..138	CDD:320219	6/25 (24%)
		TM helix 2	145..171	CDD:320219	9/26 (35%)
		TM helix 3	182..212	CDD:320219	9/29 (31%)
		TM helix 4	224..246	CDD:320219	6/22 (27%)
		TM helix 5	274..303	CDD:320219	9/28 (32%)
		TM helix 6	318..348	CDD:320219	12/42 (29%)
		TM helix 7	360..385	CDD:320219	8/24 (33%)