Protein Alignment CCKLR-17D3 and Oprl1

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001305876.1
• Gene: Oprl1 / 29256
• RGDID: 68438
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 403
• Identity: 89/403 - (22%)
• Similarity: 156/403 - (38%)
• Gaps: 134/403 - (33%)

  Fly   109 GMPVWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTL 173
            |:.|.::..|..:.:..:|||.||:..::::.:|:|.||:::.|||::|.|: :|.:|......|
  Rat    46 GLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIL 109

  Fly   174 LRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLG 238
            |..:.||..|||........::..|::||.|:|.:||.|||||:|:...:|.|.|..:...||..
  Rat   110 LGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWAL 174

  Fly   239 GILCMTPIAVFSQ----------LIPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLC 293
            ..:...|:|:...          |:....|     :::|..     .:.|.:.....::|:|::.
  Rat   175 ASVVGVPVAIMGSAQVEDEEIECLVEIPAP-----QDYWGP-----VFAICIFLFSFIIPVLIIS 229

  Fly   294 VAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNN 358
            |.|.|:.|.|. |:     |:|..|
  Rat   230 VCYSLMIRRLR-GV-----RLLSGS---------------------------------------- 248

  Fly   359 NGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLE 423
                                                            |..|..||
  Rat   249 ------------------------------------------------REKDRNLR--------- 256

  Fly   424 SKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQL---LAYSSSCCNPI 485
               |:.:::.|:|..|..||||:.|.    :|:..:..:....||::.|:.   |.|.:||.|||
  Rat   257 ---RITRLVLVVVAVFVGCWTPVQVF----VLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPI 314

  Fly   486 TYCFMNASFRRAF 498
            .|.|::.:|:..|
  Rat   315 LYAFLDENFKACF 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	87/398 (22%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	8/21 (38%)
		TM helix 3	185..207	CDD:320334	5/21 (24%)
		TM helix 4	230..246	CDD:320334	2/15 (13%)
		TM helix 5	274..297	CDD:320334	4/22 (18%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	12/27 (44%)
Oprl1	NP_001305876.1	7tmA_NOFQ_opioid_R	49..327	CDD:320220	87/398 (22%)
		TM helix 1	50..76	CDD:320220	6/25 (24%)
		TM helix 2	83..109	CDD:320220	9/26 (35%)
		TM helix 3	120..150	CDD:320220	10/29 (34%)
		TM helix 4	162..184	CDD:320220	5/21 (24%)
		TM helix 5	209..238	CDD:320220	6/33 (18%)
		TM helix 6	253..283	CDD:320220	12/45 (27%)
		TM helix 7	295..320	CDD:320220	10/24 (42%)