Protein Alignment CCKLR-17D3 and Galr2

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_062045.1
• Gene: Galr2 / 29234
• RGDID: 2657
• Length: 372
• Species: Rattus norvegicus
• Alignment Length: 484
• Identity: 116/484 - (23%)
• Similarity: 181/484 - (37%)
• Gaps: 152/484 - (31%)

  Fly    98 STPASSSSTSTGMPVW-----LIP-SYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAIS 156
            |..|.::|...|...|     |:| .:::|.|...:||.||::.|::..:..:.||:|:|||.::
  Rat     6 SQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVA 70

  Fly   157 DMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRS 221
            |:...:.|:|.......|.:::||..|||...|....::..||:||.|:|.:||.||.:||.||.
  Rat    71 DLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRE 135

  Fly   222 WQTISHAYKIIGFIWLGGILCMTPIAVF---SQL--IPTSRPGYCKCREFWPDQGYELFYNILLD 281
            .:|..:|...||.||...:|...|...:   |||  :....|.:...|....|         |..
  Rat   136 LRTPRNALAAIGLIWGLALLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMD---------LCT 191

  Fly   282 FLL-LVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSL-PVSATTAGGSAPNPGTSSSSNCILV 344
            |:. .:||:|||.:.|   .|||         |.|.::: ||
  Rat   192 FVFSYLLPVLVLSLTY---ARTL---------RYLWRTVDPV----------------------- 221

  Fly   345 LTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVH 409
                                :||.||.
  Rat   222 --------------------TAGSGSQ-------------------------------------- 228

  Fly   410 DAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQL 474
                         .:|::|.:|:.::.:.|.:||.|.:.: .:.:..|........|.......|
  Rat   229 -------------RAKRKVTRMIIIVAVLFCLCWMPHHAL-ILCVWFGRFPLTRATYALRILSHL 279

  Fly   475 LAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRRGAGASGGVGGAAGGGLSASQ---------- 529
            ::|::||.|||.|..::..||:.|.....||.......|||.|...|.|..|.|.
  Rat   280 VSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSMLEQESTDLTQ 344

  Fly   530 ----AG------AGPGAYASANTNISLNP 548
                ||      |.|...||:.|   |:|
  Rat   345 VSEAAGPLVPPPALPNCTASSRT---LDP 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	92/398 (23%)
		TM helix 1	114..138	CDD:320334	9/24 (38%)
		TM helix 2	147..169	CDD:320334	8/21 (38%)
		TM helix 3	185..207	CDD:320334	7/21 (33%)
		TM helix 4	230..246	CDD:320334	5/15 (33%)
		TM helix 5	274..297	CDD:320334	7/23 (30%)
		TM helix 6	429..451	CDD:320334	5/21 (24%)
		TM helix 7	466..491	CDD:320334	9/24 (38%)
Galr2	NP_062045.1	7tmA_Gal2_Gal3_R	26..303	CDD:320225	91/392 (23%)
		TM helix 1	27..53	CDD:320225	9/25 (36%)
		TM helix 2	60..86	CDD:320225	9/25 (36%)
		TM helix 3	98..128	CDD:320225	12/29 (41%)
		TM helix 4	140..160	CDD:320225	6/19 (32%)
		TM helix 5	184..213	CDD:320225	12/49 (24%)
		TM helix 6	229..259	CDD:320225	7/30 (23%)
		TM helix 7	271..296	CDD:320225	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..372		7/21 (33%)