Protein Alignment CCKLR-17D3 and Brs3

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_690058.1
• Gene: Brs3 / 260319
• RGDID: 628645
• Length: 399
• Species: Rattus norvegicus
• Alignment Length: 440
• Identity: 100/440 - (22%)
• Similarity: 172/440 - (39%)
• Gaps: 132/440 - (30%)

  Fly    74 DTEPSDLVTELAFSLGTSSSPSPSSTPAS-SSSTSTGMPVW--LIPSYSMILLFAVLGNLLVIST 135
            |||.|            ||:.|..:||.. :...|.|:...  :..:|::|:...:|||.::|..
  Rat    19 DTETS------------SSAVSNDTTPKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKV 71

  Fly   136 LVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSW 200
            ..:.:.|:|:.|:|:.:||..|:||.:.|:||.....|...::||:..||:..|.:..||.||.:
  Rat    72 FFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVF 136

  Fly   201 TLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLI----PTSRPGYC 261
            ||..:|.:||.|:..||..:....|.......|.||:..::...|.|:||.:.    |.....:.
  Rat   137 TLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFALPEAIFSNVYTFQDPNRNVTFE 201

  Fly   262 KCREFWP--DQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSAT 324
            .|..: |  ::..:..:::|...:..::||.::.|.|.||.||||
  Rat   202 SCNSY-PISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLY-------------------- 245

  Fly   325 TAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVIT 389
                                                            .:|..:.|.
  Rat   246 ------------------------------------------------KSTLNIPTE-------- 254

  Fly   390 TTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVM 454
                                    .:|:..|.:||:||:.|.:.|||..|.:||.|    |.::.
  Rat   255 ------------------------EQSHARKQIESRKRIAKTVLVLVALFALCWLP----NHLLY 291

  Fly   455 LIGPVVYEY------VDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAF 498
            |.....||.      |.:....|.::||:|:||.||....:::.:|::.|
  Rat   292 LYHSFTYESYAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHF 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	88/399 (22%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	10/21 (48%)
		TM helix 3	185..207	CDD:320334	8/21 (38%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	4/22 (18%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	8/24 (33%)
Brs3	NP_690058.1	7tm_GPCRs	48..341	CDD:475119	88/397 (22%)
		TM helix 1	50..74	CDD:320251	6/23 (26%)
		TM helix 2	83..105	CDD:320251	10/21 (48%)
		TM helix 3	121..143	CDD:320251	8/21 (38%)
		TM helix 4	166..182	CDD:320251	3/15 (20%)
		TM helix 5	215..238	CDD:320251	4/22 (18%)
		TM helix 6	270..292	CDD:320251	9/25 (36%)
		TM helix 7	309..334	CDD:320251	8/24 (33%)