Protein Alignment CCKLR-17D3 and GALR1

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001471.2
• Gene: GALR1 / 2587
• HGNCID: 4132
• Length: 349
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 107/435 - (24%)
• Similarity: 166/435 - (38%)
• Gaps: 131/435 - (30%)

  Fly    83 ELA---FSLGTSSSPSPSSTPASSSSTSTGMPV---WLIPSYSMILLFAVLGNLLVISTLVQNR- 140
            |||   .|.|.:|.|.|   ||.......|:.|   ..:..:.:|....||||.|||:.|.:::
Human     2 ELAVGNLSEGNASWPEP---PAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKP 63

  Fly   141 -RMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVA 204
             :.|:.||:|:|||:|:|:...:.|:|.......|..::.|.|:||...:....|:.||.:||.|
Human    64 GKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAA 128

  Fly   205 ISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPGYCKCREFWPD 269
            :|.:||.||.|..||.|.:...:|...:|.||...|...:|:|....|..........|.|.|||
Human   129 MSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPD 193

  Fly   270 QGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNPG 334
            ..::..|.:.......:||||::|..|..:...|:..:
Human   194 PRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKL--------------------------- 231

  Fly   335 TSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLA 399
                                                .||:
Human   232 ------------------------------------KNMS------------------------- 235

  Fly   400 KTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVML-IGPVVYEY 463
                           :.:||    |||:..:.:.|:|:.|.|.|.|.::|:..... :.|:
Human   236 ---------------KKSEA----SKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPL---- 277

  Fly   464 VDYTAISFL-----QLLAYSSSCCNPITYCFMNASFRRAFVDTFK 503
               |..|||     ..||||:|..|||.|.|::.:||:|:...||
Human   278 ---TPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFK 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	93/396 (23%)
		TM helix 1	114..138	CDD:320334	9/23 (39%)
		TM helix 2	147..169	CDD:320334	9/21 (43%)
		TM helix 3	185..207	CDD:320334	7/21 (33%)
		TM helix 4	230..246	CDD:320334	4/15 (27%)
		TM helix 5	274..297	CDD:320334	6/22 (27%)
		TM helix 6	429..451	CDD:320334	7/21 (33%)
		TM helix 7	466..491	CDD:320334	14/29 (48%)
GALR1	NP_001471.2	7tmA_Gal1_R	34..314	CDD:320226	92/393 (23%)
		TM helix 1	35..61	CDD:320226	9/25 (36%)
		TM helix 2	70..96	CDD:320226	10/25 (40%)
		TM helix 3	108..138	CDD:320226	12/29 (41%)
		TM helix 4	150..170	CDD:320226	5/19 (26%)
		TM helix 5	197..226	CDD:320226	7/28 (25%)
		TM helix 6	240..270	CDD:320226	11/33 (33%)
		TM helix 7	282..307	CDD:320226	12/24 (50%)