DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCKLR-17D3 and Hcrtr1

DIOPT Version :10

Sequence 1:NP_001097023.1 Gene:CCKLR-17D3 / 32864 FlyBaseID:FBgn0030954 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_037196.1 Gene:Hcrtr1 / 25593 RGDID:2787 Length:416 Species:Rattus norvegicus


Alignment Length:519 Identity:134/519 - (25%)
Similarity:212/519 - (40%) Gaps:145/519 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 PSSTPASSSS--TSTGMP--------------VW------------LIPSYSMILLFAVLGNLLV 132
            ||:||.:...  ||:|.|              :|            ||.:|..:.|.|::||.||
  Rat     3 PSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLV 67

  Fly   133 ISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAV 197
            ...:.:|..|||:||.|::||:::|:|:..:|:|.:|:..:..:::||..|||:..:.||.||:|
  Rat    68 CLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSV 132

  Fly   198 SSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIA-------VFSQLIPT 255
            :..||..|:.:|:|||||||..:|  |...|...|..||...:..|.|.|       |..:|...
  Rat   133 AVLTLSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANR 195

  Fly   256 SRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLP 320
            :|. :..|.|.|.|:.|...|:....|:..:.||.::.:||..|.|.|:                
  Rat   196 TRL-FSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLW---------------- 243

  Fly   321 VSATTAGGSAPN-PGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTA 384
                     .|. |||:|:    ||..    :...|.......:|             |.|.|  
  Rat   244 ---------GPQIPGTTSA----LVRN----WKRPSEQLEAQHQG-------------LCTEP-- 276

  Fly   385 PTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVI 449
                              .|..|...|      |.|.:.::::..|||.|::|.|.:|:.|:.|:
  Rat   277 ------------------QPRARAFLA------EVKQMRARRKTAKMLMVVLLVFALCYLPISVL 317

  Fly   450 NTMVMLIGPVVYEYVD----YTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRRG 510
            |.:..:.| :..:..|    |...:|...|.|::|..|||.|.|::..||..|...|        
  Rat   318 NVLKRVFG-MFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAF-------- 373

  Fly   511 AGASGGVGGAAGGGLSASQAGAGPGAYASANTNISLNPGLAMGMGTWRSRSRHEFLNAVVTTNS 574
                           |....|.||.: ::.:.::||....::.     ..|.|..|..|.|..|
  Rat   374 ---------------SCCLPGLGPSS-SARHKSLSLQSRCSVS-----KVSEHVVLTTVTTVLS 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCKLR-17D3NP_001097023.1 7tm_GPCRs 112..498 CDD:475119 112/409 (27%)
TM helix 1 114..138 CDD:320334 9/23 (39%)
TM helix 2 147..169 CDD:320334 8/21 (38%)
TM helix 3 185..207 CDD:320334 9/21 (43%)
TM helix 4 230..246 CDD:320334 4/15 (27%)
TM helix 5 274..297 CDD:320334 5/22 (23%)
TM helix 6 429..451 CDD:320334 9/21 (43%)
TM helix 7 466..491 CDD:320334 10/24 (42%)
Hcrtr1NP_037196.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 8/18 (44%)
Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43613 26..41 1/14 (7%)
7tmA_OXR 47..369 CDD:320336 111/397 (28%)
TM helix 1 48..74 CDD:320336 9/25 (36%)
TM helix 2 81..107 CDD:320336 10/25 (40%)
TM helix 3 119..149 CDD:320336 13/29 (45%)
TM helix 4 160..181 CDD:320336 6/20 (30%)
TM helix 5 212..241 CDD:320336 7/28 (25%)
TM helix 6 291..321 CDD:320336 10/29 (34%)
TM helix 7 337..362 CDD:320336 10/24 (42%)

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