Protein Alignment CCKLR-17D3 and Npffr1

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001170982.1
• Gene: Npffr1 / 237362
• MGIID: 2685082
• Length: 432
• Species: Mus musculus
• Alignment Length: 533
• Identity: 148/533 - (27%)
• Similarity: 203/533 - (38%)
• Gaps: 184/533 - (34%)

  Fly    73 MDTEPSDLVT-ELAFSLGTS---SSPSPSSTPASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVI 133
            |:.|||.... ....||..|   ::|..|.|.:|....|:.:....|.:|::|.|..::||.||.
Mouse     1 MEAEPSQPPNGSWPPSLNESDAETAPVASLTFSSYYQHSSPVAAMFIAAYALIFLLCMVGNTLVC 65

  Fly   134 STLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVS 198
            ..:::||.|||:||:|:||||:||:|:|:.|||.|||..|:..:.|....||:....|..||:.|
Mouse    66 FIVLKNRHMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSAS 130

  Fly   199 SWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPT-------- 255
            .:|||||:.||:..|.||.|.:  .|:..|...|..||...:|.|.|.||  .|..|
Mouse   131 VFTLVAIAVERFRCIVHPFREK--LTLRKALLTIAVIWALALLIMCPSAV--TLTVTREEHHFML 191

  Fly   256 -----SRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRIL 315
                 |.|.| .|.|.||::|....|..:|...:.:.||.::.|.|..|.|.|.
Mouse   192 DARNRSYPLY-SCWEAWPEKGMRKVYTAVLFAHIYLAPLALIVVMYARIARKLC----------- 244

  Fly   316 QQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTT 380
                         .||.|...:                        .|..|.||.
Mouse   245 -------------QAPGPARDA------------------------EEAVAEGGR---------- 262

  Fly   381 RPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTP 445
                                          |:.||:          |||.||.::.|.|.:.|.|
Mouse   263 ------------------------------ASRRRA----------RVVHMLVMVALFFTLSWLP 287

  Fly   446 LYVINTMVMLIGPVVYEYVDYTAISFLQL-------------LAYSSSCCNPITYCFMNASFRRA 497
            |:|:    :|:       :||..:|.|||             ||:..|..|||.|.:.|.:|||.
Mouse   288 LWVL----LLL-------IDYGELSELQLHLLSVYAFPLAHWLAFFHSSANPIIYGYFNENFRRG 341

  Fly   498 FVDTFKG----LPW---------RRG---------------------AGASGGVGG----AAGGG 524
            |...|:.    |||         |.|                     :|.|.||.|    ....|
Mouse   342 FQAAFRAQLCWLPWAAHKQAYSERPGRLLRRRVVVDVQPSDSGLPSESGPSSGVPGPNRLPLRNG 406

  Fly   525 LSASQAG--AGPG 535
            ..|.|.|  .|||
Mouse   407 RVAHQDGPREGPG 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	117/411 (28%)
		TM helix 1	114..138	CDD:320334	8/23 (35%)
		TM helix 2	147..169	CDD:320334	13/21 (62%)
		TM helix 3	185..207	CDD:320334	10/21 (48%)
		TM helix 4	230..246	CDD:320334	5/15 (33%)
		TM helix 5	274..297	CDD:320334	5/22 (23%)
		TM helix 6	429..451	CDD:320334	9/21 (43%)
		TM helix 7	466..491	CDD:320334	12/37 (32%)
Npffr1	NP_001170982.1	7tm_GPCRs	44..342	CDD:475119	117/411 (28%)
		TM helix 1	46..70	CDD:410628	8/23 (35%)
		TM helix 2	79..101	CDD:410628	13/21 (62%)
		TM helix 3	117..139	CDD:410628	10/21 (48%)
		TM helix 4	160..176	CDD:410628	5/15 (33%)
		TM helix 5	214..237	CDD:410628	5/22 (23%)
		TM helix 6	271..293	CDD:410628	9/25 (36%)
		TM helix 7	310..335	CDD:410628	7/24 (29%)