Protein Alignment CCKLR-17D3 and npr-22

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001023541.1
• Gene: npr-22 / 190424
• WormBaseID: WBGene00022004
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 446
• Identity: 105/446 - (23%)
• Similarity: 174/446 - (39%)
• Gaps: 115/446 - (25%)

  Fly    68 DRDGYMDTEPSDLVTELAFSLGTSSSPSPSSTPASSSST-----STGMPVWLIPSYSMILLFAVL 127
            |..|.:.:.....:|..|..:...:.|:.:..||.....     :..|.:..|..||::.:..|.
 Worm     2 DEGGGIGSSLLSRITTTASEIMMRNEPTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCCVY 66

  Fly   128 GNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLL---RNFIFGEFLCKLFQF 189
            ||:|||..:|..:|:||.||:.:||||::|:|:.|.|:|.:....|:   :.::||..:|.|..|
 Worm    67 GNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLAF 131

  Fly   190 SQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIP 254
            .||.:|.:|:||||.||.:|:.||...|......|...|..::...|:..||...|: :|:....
 Worm   132 LQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALPL-LFTTRFF 195

  Fly   255 TSRPGYCKCREFWP---DQGYEL--FYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRI 314
            ..:.|...|.|.|.   |.|.::  .|:.::..|..|:|..||.:.|      .::|:...:.|:
 Worm   196 EDQDGLPNCGENWTYFGDSGEQVRKVYSSMVLILQYVVPQAVLIITY------THIGIKMWNSRV 254

  Fly   315 LQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLT 379
                              ||..:.:
 Worm   255 ------------------PGMQNGA---------------------------------------- 261

  Fly   380 TRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWT 444
                                 |....:..|             ||.|::|.|:.::...|.:||.
 Worm   262 ---------------------TKKMIVDRH-------------ESVKKLVPMVILISALFALCWL 292

  Fly   445 PLYVINTMVMLIGPVV--YEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAF 498
            ||.::..::....|.:  :.|:.| ...|...||.|.|..|||.|...||.||..|
 Worm   293 PLLILINVIPEFYPDINSWGYILY-LWWFAHGLAMSHSMVNPIIYFIRNARFREGF 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	96/395 (24%)
		TM helix 1	114..138	CDD:320334	9/23 (39%)
		TM helix 2	147..169	CDD:320334	10/21 (48%)
		TM helix 3	185..207	CDD:320334	11/21 (52%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	6/24 (25%)
		TM helix 6	429..451	CDD:320334	7/21 (33%)
		TM helix 7	466..491	CDD:320334	10/24 (42%)
npr-22	NP_001023541.1	7tmA_PR4-like	51..347	CDD:320514	96/395 (24%)
		TM helix 1	52..78	CDD:320514	10/25 (40%)
		TM helix 2	85..110	CDD:320514	11/24 (46%)
		TM helix 3	126..156	CDD:320514	15/29 (52%)
		TM helix 4	169..190	CDD:320514	5/21 (24%)
		TM helix 5	219..248	CDD:320514	8/34 (24%)
		TM helix 6	271..301	CDD:320514	10/29 (34%)
		TM helix 7	315..340	CDD:320514	10/25 (40%)