Protein Alignment CCKLR-17D3 and npr-14

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001379223.1
• Gene: npr-14 / 189211
• WormBaseID: WBGene00012275
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 106/459 - (23%)
• Similarity: 178/459 - (38%)
• Gaps: 151/459 - (32%)

  Fly    59 NATSSYGDDDRDG------YMDT--EPSDLVTELAFSLGTSSSPSPSSTPASSSSTSTGMPVWLI 115
            |.||...::|.|.      .::|  |..|::.|..:         |::           :..|.:
 Worm     6 NVTSGSSEEDYDTSEIIGLQVNTHEEYEDIIAEALW---------PNA-----------VEQWFV 50

  Fly   116 PSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFG 180
            ...:.:::..|:||.||:..:..|:.||...|:.|:||||:|:|:.:.|:|:|:|..:.:.|.|.
 Worm    51 YILASMMVIGVIGNTLVVVVVATNKSMRNALNLVLMNLAIADLLILLFCLPLTVVNDVTKTFWFS 115

  Fly   181 EFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTP 245
            ...||...|....||.||..:||.|:|||:.||.:||:|...:|.|    :||.||...:...:|
 Worm   116 AVFCKSVNFVNNTSVYVSIMSLVFITCERWRAITYPLKSPFVRTRS----VIGGIWFIAMFLSSP 176

  Fly   246 IAVFSQL--IPTSRPGY-----CKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTL 303
            ..|...|  .|..||.:     .:|:|.|.:: ::..|.:|......||||||:.:..:.:.|||
 Worm   177 EPVTLHLAGAPFVRPNFTTKWGTRCKESWSEE-FQKNYQLLQTIFSFVLPLLVISILCLHMVRTL 240

  Fly   304 YVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGG 368
            :.                                |:|.:.|..
 Worm   241 HF--------------------------------SANYLTVAN---------------------- 251

  Fly   369 GSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLF 433
                                                               :.:..:|:.|:||.
 Worm   252 ---------------------------------------------------RQISIRKKAVRMLC 265

  Fly   434 VLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLL----AYSSSCCNPITYCFMNASF 494
            .:|..|.:...|:::.|  :.|...::...|....|:..:||    :|||||.|||.|.|::..|
 Worm   266 AVVFLFSMSNLPVHLYN--IALNYDLLSTDVSTNTIAVRKLLPRVFSYSSSCLNPILYSFLSGRF 328

  Fly   495 RRAF 498
            |..|
 Worm   329 REEF 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	95/396 (24%)
		TM helix 1	114..138	CDD:320334	5/23 (22%)
		TM helix 2	147..169	CDD:320334	10/21 (48%)
		TM helix 3	185..207	CDD:320334	9/21 (43%)
		TM helix 4	230..246	CDD:320334	4/15 (27%)
		TM helix 5	274..297	CDD:320334	8/22 (36%)
		TM helix 6	429..451	CDD:320334	6/21 (29%)
		TM helix 7	466..491	CDD:320334	13/28 (46%)
npr-14	NP_001379223.1	7tmA_CCKR-like	48..332	CDD:320124	95/395 (24%)
		TM helix 1	48..74	CDD:320124	6/25 (24%)
		TM helix 2	81..107	CDD:320124	12/25 (48%)
		TM helix 3	119..149	CDD:320124	14/29 (48%)
		TM helix 4	159..177	CDD:320124	6/21 (29%)
		TM helix 5	210..235	CDD:320124	8/24 (33%)
		TM helix 6	255..285	CDD:320124	8/31 (26%)
		TM helix 7	300..325	CDD:320124	12/24 (50%)