DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCKLR-17D3 and ckr-1

DIOPT Version :9

Sequence 1:	NP_001097023.1	Gene:	CCKLR-17D3 / 32864	FlyBaseID:	FBgn0030954	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_491918.3	Gene:	ckr-1 / 188774	WormBaseID:	WBGene00020712	Length:	421	Species:	Caenorhabditis elegans

Alignment Length:	405	Identity:	120/405 - (29%)
Similarity:	195/405 - (48%)	Gaps:	53/405 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 YSMILLFAVLGNLLVISTLV-QNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGE 181
            :.:.|:.::|||.:||.|:: ::.|.|:|||.:|||||.:|:|..::|:|.||:|.|.:.::.|.
Worm    20 FLLCLILSLLGNAIVILTILGKSHRSRSITNFYLLNLAFADLLRSIICIPSTLLGELTQCWLLGA 84

  Fly   182 FLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPI 246
            .:||:..|.|...|..|::||..|:.|||||||.||.||.|||...|...|..:|     |.:..
Worm    85 AMCKIVAFLQPVGVCASAYTLAVIAIERYYAICRPLESRKWQTKKRALITISLVW-----CFSFS 144

  Fly   247 AVFSQL-IPTSRPGYCKCREFWPDQG--YELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMA 308
            |..:.| :..:.||...|..   .:|  .:..|.:.|.|.||.:||.::...|..:..||...:.
Worm   145 ANLTSLFLYDANPGKFTCDS---TKGPLVDFIYQLYLTFTLLFVPLALMVGLYGNVIITLNTAIN 206

  Fly   309 KDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCIL----------VLTATAVYNENSNNNNGNSE 363
            .|...:.||.:..:.         |..:|.|:..:          |::.|..:.|.::.:...:.
Worm   207 SDHPTVEQQMIEKTL---------PSRASFSDWFVSAVQRVPSMKVVSKTFQFKEKNSLSIPQTS 262

  Fly   364 GSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRV 428
            |             |:.||:..:..:..:|...:...|         ..||.:|:.|.|.:||:|
Worm   263 G-------------LSVRPSRSSFSSFFSTPRGSFDVT---------MLLRSTNQEKILIAKKKV 305

  Fly   429 VKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNAS 493
            .:||..||:.|..||.|.|:...::.:......:..:....|.|.::.|.||..|||||||||.|
Worm   306 TRMLITLVIVFAFCWVPSYLYWLLLRMAELAATDLWNPGLNSSLTIMTYISSLANPITYCFMNKS 370

  Fly   494 FRRAFVDTFKGLPWR 508
            ||.:.:...:..|.|
Worm   371 FRSSVLAYCRPKPKR 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_4	120..>244	CDD:304433	53/124 (43%)
CCKLR-17D3	NP_001097023.1	7tm_1	128..487	CDD:278431	107/372 (29%)
ckr-1	NP_491918.3	7tmA_CCKR-like	30..375	CDD:320124	116/383 (30%)
		TM helix 2	50..72	CDD:320124	10/21 (48%)
		TM helix 3	88..110	CDD:320124	8/21 (38%)
		TM helix 4	133..149	CDD:320124	4/20 (20%)
		TM helix 5	172..195	CDD:320124	7/22 (32%)
		TM helix 6	303..328	CDD:320124	11/24 (46%)
		TM helix 7	343..368	CDD:320124	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E33208_3BDYY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I2204
Isobase	1	0.950	-	0	Normalized mean entropy	S5836
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1042780at2759
OrthoFinder	1	1.000	-	-		FOG0001992
OrthoInspector	1	1.000	-	-		mtm4725
orthoMCL	1	0.900	-	-		OOG6_105354
Panther	1	1.100	-	-	O	PTHR24238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1306
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.820