Protein Alignment CCKLR-17D3 and npr-12

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001293732.1
• Gene: npr-12 / 188742
• WormBaseID: WBGene00020689
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 421
• Identity: 102/421 - (24%)
• Similarity: 159/421 - (37%)
• Gaps: 151/421 - (35%)

  Fly   109 GMPVWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTL 173
            |.|:  :|.|.::..|..|.|.:|:...|:...:|.:.|.|::|||.||::|.|:..||||..:|
 Worm    41 GSPI--VPMYGLVCSFGALANFIVLLAFVRTANLRNLRNSFIVNLAFSDLILCVVTAPVTLYTSL 103

  Fly   174 LRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKI-IGFIWL 237
            ...:.||::.||.....||.:..|||.||..|:.:|......|:|   |:..:.|..: .|.:|:
 Worm   104 NLFWPFGDWSCKFLAGVQAVNTFVSSLTLAFIAMDRVLLTLCPVR---WRLAATAPLLCYGVVWI 165

  Fly   238 GGILCMTP--IAVFSQLIP------TSRP---GYCK------CREFWPDQGYELFYNILLD---- 281
            ..|:...|  :||.|:|.|      .:.|   .||.      |.|.     .|.:.|.::.
 Worm   166 ISIIVALPYALAVSSKLAPFDPWSDRATPKMLTYCNRQVPEICAEM-----QEAWDNAIVSKTTY 225

  Fly   282 -FLLL----VLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNC 341
             |::|    :|||..|..||..|            |..:|:...||.|
 Worm   226 TFVVLGIQYILPLAALAYAYFQI------------GSTIQKRSKVSRT----------------- 261

  Fly   342 ILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSI 406
              |.|...:..:|.|
 Worm   262 --VDTTRRMQMQNRN-------------------------------------------------- 274

  Fly   407 RVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPL---YVINTMVMLIGPVVYEYVDYT- 467
                               :|.:.:||:|||.:.:||.|:   :|:|.:         |.::|:
 Worm   275 -------------------RRALLLLFLLVLTYAVCWAPMNIYHVLNGL---------EIINYSQ 311

  Fly   468 -AISFLQLLAYSSSCCNPITYCFMNASFRRA 497
             ...|..|:..||:|.|||.|..:|.|||.|
 Worm   312 NMYIFCHLVGISSTCVNPIVYALVNESFRNA 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	100/418 (24%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	11/21 (52%)
		TM helix 3	185..207	CDD:320334	9/21 (43%)
		TM helix 4	230..246	CDD:320334	4/18 (22%)
		TM helix 5	274..297	CDD:320334	8/31 (26%)
		TM helix 6	429..451	CDD:320334	9/24 (38%)
		TM helix 7	466..491	CDD:320334	10/26 (38%)
npr-12	NP_001293732.1	7tmA_NPYR-like	42..343	CDD:320331	101/420 (24%)
		TM helix 1	43..69	CDD:320331	8/27 (30%)
		TM helix 2	76..101	CDD:320331	13/24 (54%)
		TM helix 3	114..144	CDD:320331	11/29 (38%)
		TM helix 4	155..176	CDD:320331	5/20 (25%)
		TM helix 5	222..251	CDD:320331	10/40 (25%)
		TM helix 6	272..302	CDD:320331	12/98 (12%)
		TM helix 7	311..336	CDD:320331	9/24 (38%)