Protein Alignment CCKLR-17D3 and tkr-2

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_500930.1
• Gene: tkr-2 / 183595
• WormBaseID: WBGene00016761
• Length: 391
• Species: Caenorhabditis elegans
• Alignment Length: 403
• Identity: 97/403 - (24%)
• Similarity: 156/403 - (38%)
• Gaps: 118/403 - (29%)

  Fly   118 YSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEF 182
            :::.:..|::||..|:..::.:|:||::||.:|.|||::|..:.|.....:........:.||.|
 Worm    68 FTLTIFLALMGNFTVMWIILYHRQMRSVTNYYLFNLAVADASISVFNTGFSWSYNYYYVWKFGSF 132

  Fly   183 LCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQ--TISHAYKIIGFIWLGGILCMTP 245
            .|::........:..|.:|::.:|.||||||.|||:.|..:  |::    ||..||....|...|
 Worm   133 YCRINNLMGITPICASVFTMIVMSIERYYAIIHPLKKRPGRRSTVT----IIIMIWFMAFLFGVP 193

  Fly   246 IAVFSQLIPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVA--YILITRTLYVGMA 308
            ..:.|           |...::...||.|:.|             .||:|  |.....:| :|..
 Worm   194 AFLAS-----------KVDVYYFYDGYTLYEN-------------PLCLADNYPGGNESL-LGQV 233

  Fly   309 KDSGRI-LQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTN 372
            .::|.| :|..||:                   |||   :.|.|.
 Worm   234 YNNGLITVQYILPL-------------------CIL---SAAYYR-------------------- 256

  Fly   373 MATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVL 437
                                 ..|.|.|         |..:.....||::.:||:...||.|:|.
 Worm   257 ---------------------VGVELRK---------DKTVGDVRHAKSVAAKKKASIMLAVVVF 291

  Fly   438 EFFICWTPLYVINTMVMLIGPV------VYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRR 496
            .|.|.|.|.......:.|:.|:      :|.|::      :..|..||:..||:.|.|||..||.
 Worm   292 IFMIVWFPYNAYYLTLHLVEPIGNKMLSLYIYIN------IYWLGMSSTVFNPVIYYFMNKRFRV 350

  Fly   497 AFVDTFKGLPWRR 509
            .|...|:.||:.|
 Worm   351 GFHHAFRWLPFVR 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	92/390 (24%)
		TM helix 1	114..138	CDD:320334	4/19 (21%)
		TM helix 2	147..169	CDD:320334	7/21 (33%)
		TM helix 3	185..207	CDD:320334	2/21 (10%)
		TM helix 4	230..246	CDD:320334	5/15 (33%)
		TM helix 5	274..297	CDD:320334	5/24 (21%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	7/24 (29%)
tkr-2	NP_500930.1	7tmA_TACR	62..352	CDD:320512	92/390 (24%)
		TM helix 1	63..89	CDD:320512	4/20 (20%)
		TM helix 2	96..122	CDD:320512	8/25 (32%)
		TM helix 3	134..164	CDD:320512	9/29 (31%)
		TM helix 4	175..196	CDD:320512	7/24 (29%)
		TM helix 5	231..260	CDD:320512	11/91 (12%)
		TM helix 6	277..307	CDD:320512	10/29 (34%)
		TM helix 7	320..345	CDD:320512	9/30 (30%)