Protein Alignment CCKLR-17D3 and tkr-3

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001343603.1
• Gene: tkr-3 / 177285
• WormBaseID: WBGene00006428
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 474
• Identity: 97/474 - (20%)
• Similarity: 177/474 - (37%)
• Gaps: 148/474 - (31%)

  Fly    49 GNGGTVSLAGNATSSYGDDDRDGYMDTEPSDLVTELAFSLGTSSSPSPSSTPASSSSTSTGMPVW 113
            |..|.::.||.|..| ||||   :.:..|.:|:                              :|
 Worm    19 GGAGVLAEAGEAELS-GDDD---FYELTPVELI------------------------------IW 49

  Fly   114 LIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFI 178
            .: .|::|...||:|||||:...:...|:|:||..|:|||..:|:..|:..:|......|.:.:.
 Worm    50 CM-LYAIIAFMAVVGNLLVLYITLFRLRVRSITTYFILNLGFADLFTGIFAIPFKFQAALFQEWF 113

  Fly   179 FGEFLCKLFQFSQAASVAVSSWTLVAISCER----YYAICHPLRSRSWQTISHAYKIIGFIWLGG 239
            ....||::..:.:..::.||.:|||..:...    :::.|..:..||      |.:.:..||:..
 Worm   114 LPRSLCRIVPYVETVALTVSVFTLVTSAVHEFRTMFFSKCSQMSPRS------AKRCVLLIWIMA 172

  Fly   240 ILCMTPIAVFS---QLIPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITR 301
            :|...|..:|.   :....:.....:|...:||.|:...||:.|..:...:|:::|..||.:|..
 Worm   173 VLVSLPHGLFHNTYEFPDDNNTSIVQCLPVYPDAGWWKTYNVYLVIIQYFVPMIILDTAYTMIAV 237

  Fly   302 TLYVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSA 366
            .::             ||                                          |:...
 Worm   238 KIW-------------SL------------------------------------------SQSRV 247

  Fly   367 GGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKM 431
            ....|.||                  |..:::....||:.::                 .::::.
 Worm   248 ELDETKMA------------------TQKISVVSMVSPNTQL-----------------SQLMRT 277

  Fly   432 LFVLVLEFFICWTPLYVINTMVML--IGPVV--YEYVDYTAISFLQLLAYSSSCCNPITYCFMNA 492
            |.::|..|.:||.||   .|.::|  :.|.:  ::|:: ....|...||.|:||.|||.|...|.
 Worm   278 LIIVVACFSLCWFPL---ETYLLLNELKPEINGWKYIN-LVFFFSHWLAMSNSCLNPIIYGLYNT 338

  Fly   493 SFRRAFVDTFK--GLPWRR 509
            .:...:...|:  |..|:|
 Worm   339 KYNEEYRRLFRQIGCIWQR 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	81/396 (20%)
		TM helix 1	114..138	CDD:320334	9/23 (39%)
		TM helix 2	147..169	CDD:320334	7/21 (33%)
		TM helix 3	185..207	CDD:320334	5/21 (24%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	6/22 (27%)
		TM helix 6	429..451	CDD:320334	7/21 (33%)
		TM helix 7	466..491	CDD:320334	10/24 (42%)
tkr-3	NP_001343603.1	7tm_GPCRs	47..344	CDD:475119	81/427 (19%)
		TM helix 1	49..73	CDD:320515	10/24 (42%)
		TM helix 2	82..104	CDD:320515	7/21 (33%)
		TM helix 3	120..142	CDD:320515	5/21 (24%)
		TM helix 4	163..179	CDD:320515	3/15 (20%)
		TM helix 5	210..233	CDD:320515	6/22 (27%)
		TM helix 6	275..297	CDD:320515	8/24 (33%)
		TM helix 7	312..337	CDD:320515	10/25 (40%)