Protein Alignment CCKLR-17D3 and Cckbr

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_031653.1
• Gene: Cckbr / 12426
• MGIID: 99479
• Length: 453
• Species: Mus musculus
• Alignment Length: 430
• Identity: 162/430 - (37%)
• Similarity: 225/430 - (52%)
• Gaps: 61/430 - (14%)

  Fly    87 SLGTSSSPSPSS--TPASSSSTSTGMPVWL-IPSYSMILLFAVLGNLLVISTLVQNRRMRTITNV 148
            ||..|||....|  ||....:.:..:.:.: |..|::|.|.:|.||:|:|..|..:||:||:||.
Mouse    27 SLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNA 91

  Fly   149 FLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAI 213
            |||:||:||:||.|.|||.||:..|:..||||..:||...:....||:||:..|.||:.|||.||
Mouse    92 FLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAI 156

  Fly   214 CHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPGYCKCREFWPDQGYELFYNI 278
            |.||::|.|||.|||.::|...||...|.|.|..|::.:.|.. |...:|...||.:..:..:::
Mouse   157 CRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVG-PRILQCMHLWPSERVQQMWSV 220

  Fly   279 LLDFLLLVLPLLVLCVAYILITRTLYVGMAKD-------SGRILQQ-SLPVSATTAGGSAPNPGT 335
            ||..||..:|.:|:.|||.||:|.||:|:..|       ..|:..| .||     .|.:||.| .
Mouse   221 LLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLP-----GGAAAPGP-V 279

  Fly   336 SSSSNCILVLTATAVYNENSNNNNGNSEGSAGG----GSTNMATTTLTTRPTAPTVITTTTTTTV 396
            ..:..|..|.:.|             .|.|.|.    ..:.:..|||||..|.|
Mouse   280 HQNGGCRHVTSLT-------------GEDSDGCYVQLPRSRLEMTTLTTPTTGP----------- 320

  Fly   397 TLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVY 461
                  .|.        .|.|:||.| :|||||:||.|:||.||:||.|:|..||.....||...
Mouse   321 ------GPG--------PRPNQAKLL-AKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGAR 370

  Fly   462 EYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDT 501
            ..:....|||:.||:|:|:|.||:.||||:..||:|.:||
Mouse   371 RALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDT 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	151/398 (38%)
		TM helix 1	114..138	CDD:320334	10/24 (42%)
		TM helix 2	147..169	CDD:320334	14/21 (67%)
		TM helix 3	185..207	CDD:320334	8/21 (38%)
		TM helix 4	230..246	CDD:320334	5/15 (33%)
		TM helix 5	274..297	CDD:320334	8/22 (36%)
		TM helix 6	429..451	CDD:320334	12/21 (57%)
		TM helix 7	466..491	CDD:320334	13/24 (54%)
Cckbr	NP_031653.1	7tm_GPCRs	55..407	CDD:475119	151/397 (38%)
		TM helix 1	57..81	CDD:320645	10/23 (43%)
		TM helix 2	90..112	CDD:320645	14/21 (67%)
		TM helix 3	128..150	CDD:320645	8/21 (38%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..276		5/23 (22%)
		TM helix 6	338..360	CDD:320645	12/21 (57%)
		TM helix 7	375..400	CDD:320645	13/24 (54%)