DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCKLR-17D3 and Cckar

DIOPT Version :9

Sequence 1:	NP_001097023.1	Gene:	CCKLR-17D3 / 32864	FlyBaseID:	FBgn0030954	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_033957.1	Gene:	Cckar / 12425	MGIID:	99478	Length:	436	Species:	Mus musculus

Alignment Length:	458	Identity:	161/458 - (35%)
Similarity:	227/458 - (49%)	Gaps:	67/458 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TEPSD--LVTELAFSLGTSSSPSPSSTPASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVISTLV 137
            |.|.:  |..|..|.|   ..|.||....|:..         |..||.|.|.:||||.|||:.|:
Mouse    15 TPPCELGLENETLFCL---DQPQPSKEWQSAVQ---------ILLYSFIFLLSVLGNTLVITVLI 67

  Fly   138 QNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTL 202
            :|:||||:||:|||:||:||::|.:.|||..|:..||::||||..:||...:....||:||::.|
Mouse    68 RNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNL 132

  Fly   203 VAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPG---YCKCR 264
            ||||.|||.|||.||:||.|||.|||.|:|...|......|||..::|.|:|.::..   ...||
Mouse   133 VAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCR 197

  Fly   265 EFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGS 329
            ...|....:..:...|..:|.::|.:|:.|||.||:..||.|:..|:.:  ::|......::||.
Mouse   198 FLLPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGIKFDASQ--KKSAKEKRLSSGGG 260

  Fly   330 APNPGTSS----SSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITT 390
            .....:||    |..|.|                                  ..:||.....:..
Mouse   261 GGGGSSSSRYEDSDGCYL----------------------------------QKSRPPRKLELQQ 291

  Fly   391 TTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVML 455
            .:        |||...|::  .:|.|..|..|.:||||::||.|:|:.||:||.|::..|.....
Mouse   292 LS--------TSSSGGRIN--RIRSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAY 346

  Fly   456 IGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRRGAGASGGVGGA 520
            ......:::..|.|||:.||:|:|||.|||.|||||..||..|:.||...|.....|..|.||..
Mouse   347 DTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVGEE 411

  Fly   521 AGG 523
            ..|
Mouse   412 EDG 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_4	120..>244	CDD:304433	65/123 (53%)
CCKLR-17D3	NP_001097023.1	7tm_1	128..487	CDD:278431	128/365 (35%)
Cckar	NP_033957.1	CholecysA-Rec_N	1..47	CDD:286302	11/43 (26%)
		7tm_4	48..>196	CDD:304433	73/147 (50%)
		7tm_1	58..378	CDD:278431	128/365 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..280		7/61 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837290
Domainoid	1	1.000	224	1.000	Domainoid score	I2543
eggNOG	1	0.900	-	-		E33208_3BDYY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3193
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001992
OrthoInspector	1	1.000	-	-		mtm8904
orthoMCL	1	0.900	-	-		OOG6_105354
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1306
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.650