Protein Alignment CCKLR-17D3 and Brs3

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_033896.2
• Gene: Brs3 / 12209
• MGIID: 1100501
• Length: 399
• Species: Mus musculus
• Alignment Length: 436
• Identity: 96/436 - (22%)
• Similarity: 169/436 - (38%)
• Gaps: 133/436 - (30%)

  Fly    88 LGTSSSPSPSSTPASSSSTSTGMPVW-------------LIPSYSMILLFAVLGNLLVISTLVQN 139
            :..::....||:..|:.:|..|   |             :..:|:.|:...:|||.::|....:.
Mouse    14 ISITNDTETSSSVVSNDTTHKG---WTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKT 75

  Fly   140 RRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVA 204
            :.|:|:.|:|:.:||..|:||.:.|:||.....|...::||:..||:..|.:..||.||.:||..
Mouse    76 KSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTI 140

  Fly   205 ISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLI----PTSRPGYCKCRE 265
            :|.:||.|:..||..:....|.......|.||:..::...|.|:||.:.    |.....:..|..
Mouse   141 LSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNS 205

  Fly   266 FWP--DQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGG 328
            : |  ::..:..:::|...:..::||.::.|.|.||.||||
Mouse   206 Y-PISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLY------------------------ 245

  Fly   329 SAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTT 393
                                                        .:|..:.|.
Mouse   246 --------------------------------------------KSTLNIPTE------------ 254

  Fly   394 TTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGP 458
                                .:|:..|.:||:||:.|.:.|||..|.:||.|    |.::.|...
Mouse   255 --------------------EQSHARKQIESRKRIAKTVLVLVALFALCWLP----NHLLYLYHS 295

  Fly   459 VVYEY------VDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAF 498
            ..||.      |.:..|.|.::||:|:||.||....:::.:|::.|
Mouse   296 FTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHF 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	90/410 (22%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	10/21 (48%)
		TM helix 3	185..207	CDD:320334	8/21 (38%)
		TM helix 4	230..246	CDD:320334	3/15 (20%)
		TM helix 5	274..297	CDD:320334	4/22 (18%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	9/24 (38%)
Brs3	NP_033896.2	7tm_GPCRs	48..341	CDD:475119	89/397 (22%)
		TM helix 1	50..74	CDD:320251	6/23 (26%)
		TM helix 2	83..105	CDD:320251	10/21 (48%)
		TM helix 3	121..143	CDD:320251	8/21 (38%)
		TM helix 4	166..182	CDD:320251	3/15 (20%)
		TM helix 5	215..238	CDD:320251	4/22 (18%)
		TM helix 6	270..292	CDD:320251	9/25 (36%)
		TM helix 7	309..334	CDD:320251	9/24 (38%)