Protein Alignment CCKLR-17D3 and npy2r

DIOPT Version :10

• Sequence 1: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_004911210.1
• Gene: npy2r / 100498351
• XenbaseID: XB-GENE-983413
• Length: 408
• Species: Xenopus tropicalis
• Alignment Length: 440
• Identity: 112/440 - (25%)
• Similarity: 186/440 - (42%)
• Gaps: 118/440 - (26%)

  Fly    74 DTEPSDLVTEL---AFSLGTSSSPSPSSTPASSSSTS-TGMPVWLIPSYSMILLFAVLGNLLVIS 134
            :....|:.||:   .::.|.::..:..:.|.....|. ..:.|.||.:||.|:|..||||.|||.
 Frog    32 ENRTEDIKTEMNTWFYAAGLTTPYNDLTKPELIDITKLLSVQVVLILAYSSIILLGVLGNSLVIY 96

  Fly   135 TLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSS 199
            .:::.:.|||:||.|::|||:||:::..||:|.|||.|||.::.||..||.|..:||..:|.||:
 Frog    97 VVIKFKTMRTVTNFFIVNLAVSDLMVNTLCLPFTLVYTLLDDWKFGTVLCHLVTYSQGLAVQVST 161

  Fly   200 WTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVF---SQLIPTSRPGYC 261
            .||:.|:.:|:..|.:.|.|:....|  .:.|||..|:...|..:|:|:|   |.::.:|.....
 Frog   162 VTLMVIALDRHRCIVYHLESKISTKI--CFMIIGITWVCSALLASPLAIFKEYSVIVISSDFQIQ 224

  Fly   262 KCREFWP--DQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSAT 324
            .|.|.||  |..|...|:|.:..:..::||.::..|||.|...|
 Frog   225 ACSERWPVGDLNYGTIYSISMLLIQYIVPLAIISYAYIRIWTKL--------------------- 268

  Fly   325 TAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVIT 389
                                                .:..|.|||:.:
 Frog   269 ------------------------------------KNHVSPGGGNDH----------------- 280

  Fly   390 TTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVM 454
                              .|             :.:::..|||..:|:.|.:||.|.:.......
 Frog   281 ------------------YH-------------QRRRKTTKMLVAVVVVFAVCWLPFHAFQLASD 314

  Fly   455 LIGPVVYEYVDYTAI-SFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFK 503
            :.|.|: :..:|..| :...::|..|:..||:.|.:||.::|.||:..||
 Frog   315 IDGKVL-DLNEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAFLTAFK 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	102/391 (26%)
		TM helix 1	114..138	CDD:320334	13/23 (57%)
		TM helix 2	147..169	CDD:320334	10/21 (48%)
		TM helix 3	185..207	CDD:320334	9/21 (43%)
		TM helix 4	230..246	CDD:320334	5/15 (33%)
		TM helix 5	274..297	CDD:320334	5/22 (23%)
		TM helix 6	429..451	CDD:320334	8/21 (38%)
		TM helix 7	466..491	CDD:320334	7/25 (28%)
npy2r	XP_004911210.1	7tmA_NPY2R	74..358	CDD:320521	102/391 (26%)
		TM helix 1	75..101	CDD:320521	13/25 (52%)
		TM helix 2	108..133	CDD:320521	13/24 (54%)
		TM helix 3	146..176	CDD:320521	11/29 (38%)
		TM helix 4	187..208	CDD:320521	7/22 (32%)
		TM helix 5	238..267	CDD:320521	8/28 (29%)
		TM helix 6	283..313	CDD:320521	8/29 (28%)
		TM helix 7	326..351	CDD:320521	6/24 (25%)