DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCKLR-17D3 and cckbra

DIOPT Version :9

Sequence 1:	NP_001097023.1	Gene:	CCKLR-17D3 / 32864	FlyBaseID:	FBgn0030954	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001108186.2	Gene:	cckbra / 100137117	ZFINID:	ZDB-GENE-060503-482	Length:	444	Species:	Danio rerio

Alignment Length:	394	Identity:	151/394 - (38%)
Similarity:	215/394 - (54%)	Gaps:	63/394 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 YSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEF 182
            ||::.|.:|.||||:|..|:.|:||||:||.|||:||:||:::.:.|:|..|:.:||.:||||..
Zfish    63 YSLVFLLSVFGNLLIIVVLIVNKRMRTVTNSFLLSLAVSDLMMAIFCIPFNLIPSLLEDFIFGAA 127

  Fly   183 LCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIA 247
            :||...:....||::|:::||||:.|||.|||:||:||:|||.|||||:|...|:..:..|.|..
Zfish   128 MCKTVAYFMGISVSISTFSLVAIAIERYSAICNPLKSRAWQTRSHAYKVIAATWVLSVAIMVPYP 192

  Fly   248 VFSQLIPTSRPGYC---KCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAK 309
            |||.|:|.::....   .||..||....|..:.:||..:|..:|.:|:.:||.||:|.||.|:..
Zfish   193 VFSILVPFNKTNNITAHMCRLEWPISQVEQTWYVLLLSILFFIPGVVMIIAYGLISRELYRGIQF 257

  Fly   310 DSGRILQQSLPVSATTAGGSAPNPGTSS----SSNCILVLTATAVYNENSNNNNGNSEGSAGGGS 370
            :    |:|....|....|   .|.|.||    |..|.:
Zfish   258 E----LEQKKDTSGVKNG---LNGGLSSCHDESDGCYI--------------------------- 288

  Fly   371 TNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSN--EAKTLESKKRVVKMLF 433
                  .::.:|.|..:.|.||:..|   ||..|          |||  ||| |.:||||::||.
Zfish   289 ------QVSKKPPAMELSTLTTSGPV---KTDRP----------RSNTSEAK-LIAKKRVIRMLI 333

  Fly   434 VLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAF 498
            ::|..||:||.|||..||............:....|||:|||:|:|:|.|||.|||||..||:|.
Zfish   334 IIVAMFFVCWMPLYSANTWKAFDQISAQRALSGAPISFIQLLSYTSACVNPIIYCFMNTRFRKAL 398

  Fly   499 VDTF 502
            :.||
Zfish   399 LATF 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D3	NP_001097023.1	7tm_4	120..>244	CDD:304433	60/123 (49%)
CCKLR-17D3	NP_001097023.1	7tm_1	128..487	CDD:278431	137/367 (37%)
cckbra	NP_001108186.2	7tm_4	63..>253	CDD:304433	85/189 (45%)
cckbra	NP_001108186.2	7tm_1	73..387	CDD:278431	137/367 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580897
Domainoid	1	1.000	229	1.000	Domainoid score	I2402
eggNOG	1	0.900	-	-		E33208_3BDYY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3097
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1042780at2759
OrthoFinder	1	1.000	-	-		FOG0001992
OrthoInspector	1	1.000	-	-		mtm6568
orthoMCL	1	0.900	-	-		OOG6_105354
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1306
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.660