Protein Alignment CG6873 and CFL2

DIOPT Version :9

• Sequence 1: NP_573321.1
• Gene: CG6873 / 32861
• FlyBaseID: FBgn0030951
• Length: 148
• Species: Drosophila melanogaster
• Sequence 2: NP_068733.1
• Gene: CFL2 / 1073
• HGNCID: 1875
• Length: 166
• Species: Homo sapiens
• Alignment Length: 138
• Identity: 40/138 - (28%)
• Similarity: 71/138 - (51%)
• Gaps: 22/138 - (15%)

  Fly     1 MASGINLSRECQHVFE--QIRK------LKQHRYAVF--VIQDEREIKVE------VLGVREANY 49
            ||||:.::.|...||.  ::||      :|:.:.||.  :..|:|:|.||      |..:.:...
Human     1 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVE 65

  Fly    50 DDFLADLQRAGSNQCRFAVYDYEYQHQCQGTLSTCLKEKLILMLWCPTLARIKDKMLYSSTFAVL 114
            |.:.:.::....|.||:|:||..|:      .....||.|:.:.|.|..|.:|.||:|:|:...:
Human    66 DPYTSFVKLLPLNDCRYALYDATYE------TKESKKEDLVFIFWAPESAPLKSKMIYASSKDAI 124

  Fly   115 KREFPGVQ 122
            |::|.|::
Human   125 KKKFTGIK 132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6873	NP_573321.1	ADF_cofilin_like	3..142	CDD:200442	38/136 (28%)
CFL2	NP_068733.1	Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	2..55		16/52 (31%)
		ADF_cofilin_like	3..153	CDD:200442	38/136 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	30..34		1/3 (33%)
		Interaction with CSRP3. /evidence=ECO:0000269|PubMed:19752190	55..105		12/55 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160368
Domainoid	1	1.000	65	1.000	Domainoid score	I10024
eggNOG	1	0.900	-	-		E1_KOG1735
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	72	1.000	Inparanoid score	I5302
Isobase	1	0.950	-	0	Normalized mean entropy	S1466
OMA	1	1.010	-	-		QHG53544
OrthoDB	1	1.010	-	-		D1370477at2759
OrthoFinder	1	1.000	-	-		FOG0000392
OrthoInspector	1	1.000	-	-		mtm8616
orthoMCL	1	0.900	-	-		OOG6_100500
Panther	1	1.100	-	-	O	PTHR11913
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2387
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.790