Protein Alignment CCKLR-17D1 and CCKBR

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 169/555 - (30%)
• Similarity: 271/555 - (48%)
• Gaps: 96/555 - (17%)

  Fly    98 IHLNASNEISAVGDGVTITGTPGDLLNYSGLELDLGLDLDLNLDMDLATTPSSSTLAPAVTVRTP 162
            :.||.|.:.:..|.|.::......|||.|.:.             :|:..|.        .:|..
Human     4 LKLNRSVQGTGPGPGASLCRPGAPLLNSSSVG-------------NLSCEPP--------RIRGA 47

  Fly   163 GNRSV---VRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILL 224
            |.|.:   :|::         .|:.|.|.:|.||:|:::.|..:||:||:||.|||:||:||:||
Human    48 GTRELELAIRIT---------LYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLL 103

  Fly   225 GVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTI 289
            .|.|||.||:..|:..||||.::||.:.:....||:||:.:||||:.|||.|||.||::|.|||.
Human   104 AVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTR 168

  Fly   290 NHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLP 354
            :||.::|...||.|.:.|.|...::.:.|.. |.:.:|..:||  |....:.:::.|.|.|..:|
Human   169 SHAARVIVATWLLSGLLMVPYPVYTVVQPVG-PRVLQCVHRWP--SARVRQTWSVLLLLLLFFIP 230

  Fly   355 LLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPH 419
            .:.::..|..|:|.||:.:|.:     |.|.           :::.|:.|..|.        :|.
Human   231 GVVMAVAYGLISRELYLGLRFD-----GDSD-----------SDSQSRVRNQGG--------LPG 271

  Fly   420 QHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGG----- 479
            ...|.:|:...::.:...|..|      .||...:.|     :|......|..::.:||.
Human   272 GAGPREQNLGEAELWRATGPAG------VGGTEMKVR-----VRRKLEMELSWERRSGGDWAGDW 325

  Fly   480 GTLSGTGAGNGECCSRVHRM-RQQMQLQQQGYVSDNESRRKSLSQPSLRITE-------AGLRRS 536
            |....:...:..|...||:. |.:.:....|..||....:...|:|:|.:|.       :| .|.
Human   326 GDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSG-SRP 389

  Fly   537 NETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSC 601
            .:.|.| :|||||:||.|:|:.||:||.|:|..||.....||..:..:....|||:.||:|:|:|
Human   390 TQAKLL-AKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASAC 453

  Fly   602 CNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCC 636
            .||:.||||:..||:|.::|          ||.||
Human   454 VNPLVYCFMHRRFRQACLET----------CARCC 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	148/453 (33%)
		TM helix 1	178..202	CDD:410628	8/23 (35%)
		TM helix 2	211..233	CDD:410628	14/21 (67%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	11/21 (52%)
		TM helix 7	586..611	CDD:410628	13/24 (54%)
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	149/463 (32%)
		TM helix 1	57..81	CDD:320645	9/32 (28%)
		TM helix 2	90..112	CDD:320645	14/21 (67%)
		TM helix 3	128..150	CDD:320645	9/21 (43%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	4/22 (18%)
		TM helix 6	401..423	CDD:320645	11/21 (52%)
		TM helix 7	438..463	CDD:320645	13/24 (54%)