Protein Alignment CCKLR-17D1 and GALR2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_003848.1
• Gene: GALR2 / 8811
• HGNCID: 4133
• Length: 387
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 103/494 - (20%)
• Similarity: 169/494 - (34%)
• Gaps: 184/494 - (37%)

  Fly   178 VVP-CYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHF 241
            :|| .::.|.|...|||.||:..|::..:..:.||:|:|||.::|:...:.|:|.......|..:
Human    27 IVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGW 91

  Fly   242 IFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVC 306
            :||.||||.:.|....::..||:||.|:|.:||.||.:||.||..:|..:|...|.:||..||:.
Human    92 VFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLF 156

  Fly   307 MTPIAAF---SQLMPTSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRT 368
            ..|..::   |||     ..|..|...|.|..   .||.::...:...:||:|.|..||   .||
Human   157 SGPYLSYYRQSQL-----ANLTVCHPAWSAPR---RRAMDICTFVFSYLLPVLVLGLTY---ART 210

  Fly   369 LYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQY 433
            |
Human   211 L---------------------------------------------------------------- 211

  Fly   434 YYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHR 498
                                   |:|:                   ..:....||:|
Human   212 -----------------------RYLW-------------------RAVDPVAAGSG-------- 226

  Fly   499 MRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICW 563
                             :||                         :|::|.:|:.::...|.:||
Human   227 -----------------ARR-------------------------AKRKVTRMILIVAALFCLCW 249

  Fly   564 TPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGM--- 625
            .|.:.: .:.:..|........|.......|::|::||.|||.|..::..||:.|.....|:
Human   250 MPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGR 313

  Fly   626 ---RVCERLCAPC------CFWRRRSKNETNLSVAGNSI 655
               |...|:||..      ....|.|.:..::|.|..::
Human   314 APGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGAL 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	93/443 (21%)
		TM helix 1	178..202	CDD:410628	10/24 (42%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	7/21 (33%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	7/22 (32%)
		TM helix 6	549..571	CDD:410628	5/21 (24%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)
GALR2	NP_003848.1	7tmA_Gal2_Gal3_R	26..303	CDD:320225	93/443 (21%)
		TM helix 1	27..53	CDD:320225	10/25 (40%)
		TM helix 2	60..86	CDD:320225	9/25 (36%)
		TM helix 3	98..128	CDD:320225	12/29 (41%)
		TM helix 4	140..160	CDD:320225	6/19 (32%)
		TM helix 5	184..213	CDD:320225	11/118 (9%)
		TM helix 6	229..259	CDD:320225	8/55 (15%)
		TM helix 7	271..296	CDD:320225	9/24 (38%)