Protein Alignment CCKLR-17D1 and KISS1R

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_047295501.1
• Gene: KISS1R / 84634
• HGNCID: 4510
• Length: 459
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 139/522 - (26%)
• Similarity: 214/522 - (40%)
• Gaps: 153/522 - (29%)

  Fly   144 LATT-PSSSTLAPAVTVRTPG---NRSVVRVSADVPI--------WVVPC-YSAILLCAVVGNLL 195
            :||: |::|..|||.....||   |.|      |.|:        |:||. ::|::|..:|||.|
Human     4 VATSGPNASWGAPANASGCPGCGANAS------DGPVPSPRAVDAWLVPLFFAALMLLGLVGNSL 62

  Fly   196 VVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVA 260
            |:..:.:::.|||:||.::.|||.:|:...:.|:|.|.:...|..::.|:.:||.:.:.|..||.
Human    63 VIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQ 127

  Fly   261 VSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLR 325
            .:..||.|:|.:|:|....|||:...:|...|..:...||:||.....|:.|..:|.|..|   .
Human   128 ATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPR---A 189

  Fly   326 KCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTL-YVSMRNERAMNFGSSGPEVT 389
            .|.|.:|:.:|  |||:.|:..|||.:|||||....|..:.|.| .|::|
Human   190 YCSEAFPSRAL--ERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVR--------------- 237

  Fly   390 TSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCE 454
                .|.|::..|.|..|.
Human   238 ----PAPADSALQVRGVGG---------------------------------------------- 252

  Fly   455 GRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRK 519
                            |..::.|.|||:.| |||.|.|..|      .......|.|..:|..|
Human   253 ----------------RTARLGGRGGTVVG-GAGGGICAGR------DSPRGPGGAVRGDELSR- 293

  Fly   520 SLSQPSLRIT-------------EAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINT 571
               .|:.|:|             .||..|:          :|.:::..:||.|..||.|:.:. .
Human   294 ---APAFRLTTFTAPPQGQVLAERAGAVRA----------KVSRLVAAVVLLFAACWGPIQLF-L 344

  Fly   572 MTMLLGPT----VYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLC 632
            :...|||.    ...|..|...::...::||:|..||:.|.|:.:.||:||      .|||.  |
Human   345 VLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAF------RRVCP--C 401

  Fly   633 AP 634
            ||
Human   402 AP 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	118/459 (26%)
		TM helix 1	178..202	CDD:410628	9/24 (38%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	7/21 (33%)
		TM helix 4	294..310	CDD:410628	4/15 (27%)
		TM helix 5	340..363	CDD:410628	11/22 (50%)
		TM helix 6	549..571	CDD:410628	6/21 (29%)
		TM helix 7	586..611	CDD:410628	8/24 (33%)
KISS1R	XP_047295501.1	7tm_GPCRs	43..395	CDD:475119	118/459 (26%)
		TM helix 1	45..69	CDD:410628	9/23 (39%)
		TM helix 2	78..100	CDD:410628	7/21 (33%)
		TM helix 3	116..138	CDD:410628	7/21 (33%)
		TM helix 4	161..177	CDD:410628	4/15 (27%)
		TM helix 5	202..225	CDD:410628	11/22 (50%)
		TM helix 6	323..345	CDD:410628	6/22 (27%)
		TM helix 7	363..388	CDD:410628	8/24 (33%)