Protein Alignment CCKLR-17D1 and QRFPR

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 98/480 - (20%)
• Similarity: 170/480 - (35%)
• Gaps: 185/480 - (38%)

  Fly   153 LAPAV-TVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLN 216
            |.|.| |...||...:..|...|.|:.:         |:.||.||...:.:::.|||:||:|:.:
Human    31 LRPLVYTPELPGRAKLALVLTGVLIFAL---------ALFGNALVFYVVTRSKAMRTVTNIFICS 86

  Fly   217 LAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPL 281
            ||:||:|:..||:|||::..:..:::.|..:||::.|.|:.:|.....|:..|:.||:..:.||.
Human    87 LALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPF 151

  Fly   282 RSRTWQTIN-HANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRK----CREQWPADSLNYERA 341
            :.: ||..| .|..::.::||.:::..:|:....||.........|    |.|:|  .|..:::.
Human   152 KMK-WQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEW--TSPVHQKI 213

  Fly   342 YNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRAN 406
            |..|:.:.|.:|||:.:...|..|...|::..|
Human   214 YTTFILVILFLLPLMVMLILYSKIGYELWIKKR-------------------------------- 246

  Fly   407 GSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLR 471
                                                                             
Human   247 ----------------------------------------------------------------- 246

  Fly   472 HQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRS 536
                           .|:|.....:|                    .|.:|
Human   247 ---------------VGDGSVLRTIH--------------------GKEMS-------------- 262

  Fly   537 NETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTS----------ISF 591
               |....|||.|.|:..:|..|.:||.|.:|::.|        .||..:..          .:.
Human   263 ---KIARKKKRAVIMMVTVVALFAVCWAPFHVVHMM--------IEYSNFEKEYDDVTIKMIFAI 316

  Fly   592 LQLLAYSSSCCNPITYCFMNASFRR 616
            :|::.:|:|.||||.|.|||.:|::
Human   317 VQIIGFSNSICNPIVYAFMNENFKK 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	89/455 (20%)
		TM helix 1	178..202	CDD:410628	5/23 (22%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	6/21 (29%)
		TM helix 4	294..310	CDD:410628	2/15 (13%)
		TM helix 5	340..363	CDD:410628	6/22 (27%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	9/34 (26%)
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	92/465 (20%)
		TM helix 1	47..73	CDD:320333	8/34 (24%)
		TM helix 2	80..106	CDD:320333	13/25 (52%)
		TM helix 3	118..148	CDD:320333	9/29 (31%)
		TM helix 4	161..182	CDD:320333	4/20 (20%)
		TM helix 5	211..236	CDD:320333	7/24 (29%)
		TM helix 6	266..296	CDD:320333	12/37 (32%)
		TM helix 7	311..336	CDD:320333	9/24 (38%)