DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCKLR-17D1 and Gpr146

DIOPT Version :9

Sequence 1:	NP_001097021.1	Gene:	CCKLR-17D1 / 32860	FlyBaseID:	FBgn0259231	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001033792.1	Gene:	Gpr146 / 80290	MGIID:	1933113	Length:	333	Species:	Mus musculus

Alignment Length:	471	Identity:	95/471 - (20%)
Similarity:	144/471 - (30%)	Gaps:	186/471 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 IWVVPCYSAILLCAVVG-----NLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVG 235
            :||:   |.:.|.|.|.     |.|:||..:.::...|:.:|:.:|:|::.::|.... |..|:|
Mouse    25 LWVL---SLLYLGAGVPVSLGYNALLVLANLASKNTMTMPDVYFVNMAVAGLVLTALA-PAYLLG 85

  Fly   236 TLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIW 300
            .                       |.|.|.|.::|.|.:..                  ::.:..
Mouse    86 P-----------------------AHSRWALWSLSSEAHVT------------------LLILFN 109

  Fly   301 LGSLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNY--ERAYNLFLDLALLVLPLLALSFTYL 363
            :.|||.|...|..                     ||:|  |||           ||
Mouse   110 VASLVTMYSTALL---------------------SLDYYIERA-----------LP--------- 133

  Fly   364 FITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHH 428
               ||...|:.|.|.:.....|..|.||.|
Mouse   134 ---RTYMASVYNTRHVCGFVWGGAVLTSFS----------------------------------- 160

  Fly   429 HHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECC 493
              |..:|...|..|              |...|.|..                       |.|..
Mouse   161 --SLLFYICSHVSS--------------RIAECARMQ-----------------------NTEAA 186

  Fly   494 SRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLE 558
            ..:        |...|||....:...:|:..| ||.:.......:|..|:..  |.::|...|..
Mouse   187 DAI--------LVLIGYVVPGLAVLYALALIS-RIGKEDTPLDQDTSRLDPS--VHRLLVATVCT 240

  Fly   559 FFICWTPLYVINTMTMLL--GPTVY-EYVGYTSIS--FLQLLAYSSSCCNPITYCFMNASFRRAF 618
            .|..|||.|:....|:|.  |.||. .|:|...::  ..:.||:|||...|:.|.::|.:|....
Mouse   241 QFGLWTPYYLSLGHTVLTSRGRTVEGHYLGILQVAKDLAKFLAFSSSSVTPLLYRYINKAFPGKL 305

  Fly   619 VDTFKGMRVCERLCAP 634
            ....|.|....|.|:|
Mouse   306 RRLMKKMHCGRRHCSP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_4	185..>308	CDD:304433	24/127 (19%)
CCKLR-17D1	NP_001097021.1	7tm_1	192..>380	CDD:278431	36/194 (19%)
Gpr146	NP_001033792.1	7tmA_GPR146	27..305	CDD:320121	89/451 (20%)
		TM helix 1	28..54	CDD:320121	8/28 (29%)
		TM helix 2	61..85	CDD:320121	6/24 (25%)
		TM helix 3	101..131	CDD:320121	9/68 (13%)
		TM helix 4	142..163	CDD:320121	8/57 (14%)
		TM helix 5	183..210	CDD:320121	6/34 (18%)
		TM helix 6	225..254	CDD:320121	9/30 (30%)
		TM helix 7	273..298	CDD:320121	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8309
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950