Protein Alignment CCKLR-17D1 and npy2rl

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001314731.1
• Gene: npy2rl / 795311
• ZFINID: ZDB-GENE-111115-4
• Length: 373
• Species: Danio rerio
• Alignment Length: 524
• Identity: 117/524 - (22%)
• Similarity: 188/524 - (35%)
• Gaps: 200/524 - (38%)

  Fly   115 ITGTPGDLLNYSGLELDLGLD-LDLNLDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWV 178
            |.|:.|      ..:|.:|.| .||.|:..|.....|:.|                  ..|.:.:
Zfish     7 INGSSG------SKDLSIGEDSSDLTLNHPLLELGDSTKL------------------LGVQVVL 47

  Fly   179 VPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIF 243
            :..||.|:|..||||.||:..:.:.:.:||:||.|:.|||::|:|:...|:|.||..||||.:.|
Zfish    48 ILAYSTIILLGVVGNSLVIYVVYKFKTLRTVTNFFIANLAVADLLVNTLCLPFTLAYTLLREWKF 112

  Fly   244 GELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMT 308
            |::||..:.:||..:|.||:.||..|:.:|:..|.:.|.:|  .:.:....:|||.|:.|.|..:
Zfish   113 GQVLCFTLPYAQGLAVHVSTITLNVIALDRHRCIVYHLDTR--MSKDTCFLVIAITWVVSAVLAS 175

  Fly   309 PIAAFSQ-----LMPTSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRT 368
            |:|.|.:     |.|.:  .:..|.|:|| ||......|::...|...||||..:||.|:    .
Zfish   176 PLAIFREYGIVDLSPDN--SIEVCGEKWP-DSSTDSTLYSISTLLLQYVLPLAIISFAYI----R 233

  Fly   369 LYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQY 433
            ::..:||.                   |:..|...|                       ||.
Zfish   234 IWSKLRNH-------------------VSPVGRNDR-----------------------HHR--- 253

  Fly   434 YYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHR 498
                                                                             
Zfish   254 ----------------------------------------------------------------- 253

  Fly   499 MRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICW 563
                              |||:                            .|||..:|:.|.:.|
Zfish   254 ------------------RRKT----------------------------TKMLVTMVVVFAVSW 272

  Fly   564 TPLYVINTMTMLLGPTVYEYVGYTSI-SFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRV 627
            .|.:... :.:.:..:|.:...:..: :...::|..|:..||:.|.:||.::|.|||..|   |.
Zfish   273 LPFHAFQ-LAIDIDHSVLDMKDFRLLYTVFHIVAMCSTFANPLLYGWMNRNYRSAFVAVF---RC 333

  Fly   628 CERL 631
            .|||
Zfish   334 KERL 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	96/446 (22%)
		TM helix 1	178..202	CDD:410628	10/23 (43%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	8/22 (36%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	5/25 (20%)
npy2rl	NP_001314731.1	7tm_GPCRs	45..327	CDD:475119	96/447 (21%)
		TM helix 1	47..71	CDD:410628	10/23 (43%)
		TM helix 2	80..102	CDD:410628	9/21 (43%)
		TM helix 3	118..140	CDD:410628	8/21 (38%)
		TM helix 4	161..177	CDD:410628	6/15 (40%)
		TM helix 5	209..232	CDD:410628	8/22 (36%)
		TM helix 6	258..280	CDD:410628	7/22 (32%)
		TM helix 7	295..320	CDD:410628	5/24 (21%)