Protein Alignment CCKLR-17D1 and TACR2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001048.2
• Gene: TACR2 / 6865
• HGNCID: 11527
• Length: 398
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 120/535 - (22%)
• Similarity: 185/535 - (34%)
• Gaps: 191/535 - (35%)

  Fly   137 DLNLDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLV 201
            |:..:.::::.|.|:         |.|..:....|..:.:|.. .|.|::|.||.||.:|:..::
Human     5 DIVTEANISSGPESN---------TTGITAFSMPSWQLALWAT-AYLALVLVAVTGNAIVIWIIL 59

  Fly   202 QNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTL 266
            .:|||||:||.|::|||::|:.:..|......|......:.||...|.........::.||.:::
Human    60 AHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSM 124

  Fly   267 VAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQW 331
            .||:.:||.||.||.:.|.  :......:||.|||.:|...:|...:|.:  |...|..||...|
Human   125 TAIAADRYMAIVHPFQPRL--SAPSTKAVIAGIWLVALALASPQCFYSTV--TMDQGATKCVVAW 185

  Fly   332 PADSLNYE-RAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAA 395
            |.||.... ..|:|.:...:..|||..:...|..|..||:
Human   186 PEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLW------------------------- 225

  Fly   396 VAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLY 460
                   |||           ||    .||.|             |:
Human   226 -------RRA-----------VP----GHQAH-------------GA------------------ 237

  Fly   461 CMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPS 525
                    :|||
Human   238 --------NLRH----------------------------------------------------- 241

  Fly   526 LRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSIS 590
                            |::.|:.||.:.::||.|.|||.|.:    :..:||....:...:..|.
Human   242 ----------------LQAMKKFVKTMVLVVLTFAICWLPYH----LYFILGSFQEDIYCHKFIQ 286

  Fly   591 FLQL----LAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSKNETNLSVA 651
            .:.|    ||.||:..|||.||.:|..||..|           ||...||.|...:| |..|.:.
Human   287 QVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF-----------RLAFRCCPWVTPTK-EDKLELT 339

  Fly   652 GNSIALANSVMSSHT 666
            ..: :|:..|...||
Human   340 PTT-SLSTRVNRCHT 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	101/445 (23%)
		TM helix 1	178..202	CDD:410628	8/23 (35%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	11/28 (39%)
TACR2	NP_001048.2	7tmA_SKR_NK2R	34..318	CDD:320670	101/447 (23%)
		TM helix 1	35..61	CDD:320670	9/26 (35%)
		TM helix 2	68..94	CDD:320670	9/25 (36%)
		TM helix 3	106..136	CDD:320670	8/29 (28%)
		TM helix 4	147..168	CDD:320670	7/20 (35%)
		TM helix 5	194..223	CDD:320670	7/28 (25%)
		TM helix 6	243..273	CDD:320670	10/33 (30%)
		TM helix 7	286..311	CDD:320670	10/24 (42%)