Protein Alignment CCKLR-17D1 and BRS3

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001718.1
• Gene: BRS3 / 680
• HGNCID: 1113
• Length: 399
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 109/544 - (20%)
• Similarity: 188/544 - (34%)
• Gaps: 198/544 - (36%)

  Fly   146 TTPSSSTLAPAVTVR------TPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNR 204
            |..|||.::...|.:      :||      :.|...|::.  |:.|:...::||.:::....:.:
Human    20 TESSSSVVSNDNTNKGWSGDNSPG------IEALCAIYIT--YAVIISVGILGNAILIKVFFKTK 76

  Fly   205 RMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAI 269
            .|:|:.|:|:.:||..|:||.:.|:||.....|...::||.:.||::.|.:..||.||.:||..:
Human    77 SMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTIL 141

  Fly   270 SCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLM----PTSRPGLRKCREQ 330
            |.:||.|:..||..:....|.........:|:.|::...|.|.||.:.    |........| ..
Human   142 SADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESC-TS 205

  Fly   331 WPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAA 395
            :|......:..::|...|...::||..:|..|..|.||||.|..|
Human   206 YPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLN-------------------- 250

  Fly   396 VAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLY 460
                                 :|.:...|.:
Human   251 ---------------------IPTEEQSHAR---------------------------------- 260

  Fly   461 CMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPS 525
                                                                             
Human   261 ----------------------------------------------------------------- 260

  Fly   526 LRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTP---LYVINTMT--MLLGPTVYEYVG 585
                          |.:||:||:.:.:.|||..|.:||.|   ||:.::.|  ..:.|:...::
Human   261 --------------KQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFI- 310

  Fly   586 YTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVC---ERLCAPCCFWRRRSKNETN 647
            :|  .|.::||:|:||.||....:::.||::    .||....|   ||...|..     ..:.|.
Human   311 FT--IFSRVLAFSNSCVNPFALYWLSKSFQK----HFKAQLFCCKAERPEPPVA-----DTSLTT 364

  Fly   648 LSVAG-----NSIALANSVMSSHT 666
            |:|.|     .||.::...::|.|
Human   365 LAVMGTVPGTGSIQMSEISVTSFT 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	86/449 (19%)
		TM helix 1	178..202	CDD:410628	4/23 (17%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	2/15 (13%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	9/24 (38%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)
BRS3	NP_001718.1	7tmA_BRS-3	48..341	CDD:320251	87/456 (19%)
		TM helix 1	49..75	CDD:320251	5/27 (19%)
		TM helix 2	82..108	CDD:320251	10/25 (40%)
		TM helix 3	120..150	CDD:320251	13/29 (45%)
		TM helix 4	162..182	CDD:320251	2/19 (11%)
		TM helix 5	214..239	CDD:320251	6/24 (25%)
		TM helix 6	264..294	CDD:320251	13/29 (45%)
		TM helix 7	309..334	CDD:320251	9/27 (33%)