Protein Alignment CCKLR-17D1 and SSTR4

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001043.2
• Gene: SSTR4 / 6754
• HGNCID: 11333
• Length: 388
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 108/492 - (21%)
• Similarity: 178/492 - (36%)
• Gaps: 182/492 - (36%)

  Fly   145 ATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTI 209
            |...||:.......|..||:   .|.:..|.|..:  |:.:.|..:|||.||:..:::..:|:|.
Human    22 AANASSAPAEAEEAVAGPGD---ARAAGMVAIQCI--YALVCLVGLVGNALVIFVILRYAKMKTA 81

  Fly   210 TNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERY 274
            ||::|||||::|.|. :..:|.......|||:.||.:||:.:......::..|.:.|..:|.:||
Human    82 TNIYLLNLAVADELF-MLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRY 145

  Fly   275 YAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNYE 339
            .|:.||||:.|::..:.|..|...:||.||:...|||.|:...|........|..|||..:  :.
Human   146 VAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPA--WS 208

  Fly   340 RAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRR 404
            ..:.::..|...:||:||:...||.|..    .||                   |....||.|:|
Human   209 AVFVVYTFLLGFLLPVLAIGLCYLLIVG----KMR-------------------AVALRAGWQQR 250

  Fly   405 ANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKS 469
                                                                             
Human   251 ----------------------------------------------------------------- 250

  Fly   470 LRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLR 534
                                                                            |
Human   251 ----------------------------------------------------------------R 251

  Fly   535 RSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSS 599
            |        |:|::.:::.::|:.|.:||.|.||:..:.:.: .::...|.:.|:    :|:|::
Human   252 R--------SEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFV-TSLDATVNHVSL----ILSYAN 303

  Fly   600 SCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCC 636
            ||.|||.|.|::.:|||.|      .||   ||..||
Human   304 SCANPILYGFLSDNFRRFF------QRV---LCLRCC 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	92/440 (21%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	2/21 (10%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	10/24 (42%)
SSTR4	NP_001043.2	7tmA_SSTR4	48..322	CDD:320639	94/443 (21%)
		TM helix 1	49..75	CDD:320639	8/27 (30%)
		TM helix 2	82..108	CDD:320639	10/26 (38%)
		TM helix 3	119..149	CDD:320639	7/29 (24%)
		TM helix 4	161..183	CDD:320639	8/21 (38%)
		TM helix 5	208..237	CDD:320639	8/32 (25%)
		TM helix 6	252..282	CDD:320639	10/37 (27%)
		TM helix 7	290..315	CDD:320639	11/28 (39%)