Protein Alignment CCKLR-17D1 and SSTR2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001041.1
• Gene: SSTR2 / 6752
• HGNCID: 11331
• Length: 369
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 90/448 - (20%)
• Similarity: 163/448 - (36%)
• Gaps: 185/448 - (41%)

  Fly   182 YSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISD--ILLGV--FCMPVTLVGTLLRHFI 242
            |..:.:..:.||.||:..:::..:|:||||:::|||||:|  .:||:  ..|.|.||     |:.
Human    50 YFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALV-----HWP 109

  Fly   243 FGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCM 307
            ||:.:|:::......:...|.:.|..:|.:||.|:.||::|..|:....|..|...:|..||:.:
Human   110 FGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVI 174

  Fly   308 TPIAAFSQLMPTSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVS 372
            .||..::.|. :::.|...|...||.:|..:...:.::..:...::||..:...||||.
Human   175 LPIMIYAGLR-SNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFII------ 232

  Fly   373 MRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDY 437
                                                                             
Human   233 ----------------------------------------------------------------- 232

  Fly   438 GHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQ 502
                                       ..|||             ||...|:
Human   233 ---------------------------IKVKS-------------SGIRVGS------------- 244

  Fly   503 MQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLY 567
                         |:||                       :|:|:|.:|:.::|..|..||.|.|
Human   245 -------------SKRK-----------------------KSEKKVTRMVSIVVAVFIFCWLPFY 273

  Fly   568 VIN--TMTMLLGPT-----VYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAF 618
            :.|  :::|.:.||     :::        |:.:|.|::||.|||.|.|::.:|:::|
Human   274 IFNVSSVSMAISPTPALKGMFD--------FVVVLTYANSCANPILYAFLSDNFKKSF 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	89/446 (20%)
		TM helix 1	178..202	CDD:410628	5/19 (26%)
		TM helix 2	211..233	CDD:410628	11/25 (44%)
		TM helix 3	249..271	CDD:410628	2/21 (10%)
		TM helix 4	294..310	CDD:410628	4/15 (27%)
		TM helix 5	340..363	CDD:410628	2/22 (9%)
		TM helix 6	549..571	CDD:410628	8/23 (35%)
		TM helix 7	586..611	CDD:410628	10/24 (42%)
SSTR2	NP_001041.1	7tmA_SSTR2	44..323	CDD:320637	89/446 (20%)
		TM helix 1	45..71	CDD:320637	5/20 (25%)
		TM helix 2	78..104	CDD:320637	11/25 (44%)
		TM helix 3	115..145	CDD:320637	7/29 (24%)
		TM helix 4	157..179	CDD:320637	7/21 (33%)
		TM helix 5	205..234	CDD:320637	6/126 (5%)
		TM helix 6	249..279	CDD:320637	11/29 (38%)
		TM helix 7	291..316	CDD:320637	10/32 (31%)