Protein Alignment CCKLR-17D1 and SSTR1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001040.1
• Gene: SSTR1 / 6751
• HGNCID: 11330
• Length: 391
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 106/524 - (20%)
• Similarity: 185/524 - (35%)
• Gaps: 204/524 - (38%)

  Fly   145 ATTPSSS-TLAPAVTVRTPGNRSVVRVSAD--------------------VPIWVVPCYSAILLC 188
            |::|||| :.:|.......|:|.....:||                    ..|.:...||.:.|.
Human     7 ASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLV 71

  Fly   189 AVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQF 253
            .:.||.:|:..:::..:|:|.||:::|||||:|.|| :..:|..:..|||||:.||.|||:|:..
Human    72 GLCGNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRHWPFGALLCRLVLS 135

  Fly   254 AQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMP 318
            ..|.::..|.:.|..:|.:||.|:.||:::..::....|..:...:|:.||:.:.||..||:...
Human   136 VDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAA 200

  Fly   319 TSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTY-LFITRTLYVSMRNERAMNFG 382
            .| .|...|....|..:..:...:.|:..|...:||:.|:...| |.|.:...|:::
Human   201 NS-DGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK-------- 256

  Fly   383 SSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLI 447
                            ||.|:|                                      ||
Human   257 ----------------AGWQQR--------------------------------------KR--- 264

  Fly   448 SGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVS 512
                                                                             
Human   265 ----------------------------------------------------------------- 264

  Fly   513 DNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLG 577
                                           |::::..|:.::|:.|.|||.|.||:..:
Human   265 -------------------------------SERKITLMVMMVVMVFVICWMPFYVVQLV----- 293

  Fly   578 PTVYEYVGYTSISFLQ-LLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRR 641
             .|:......::|.|. :|.|::||.|||.|.|::.:|:|:|          :|:.  |..|...
Human   294 -NVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSF----------QRIL--CLSWMDN 345

  Fly   642 SKNE 645
            :..|
Human   346 AAEE 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	90/442 (20%)
		TM helix 1	178..202	CDD:410628	6/23 (26%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	6/23 (26%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	11/25 (44%)
SSTR1	NP_001040.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		10/42 (24%)
		7tmA_SSTR1	59..334	CDD:320636	91/443 (21%)
		TM helix 1	60..86	CDD:320636	6/25 (24%)
		TM helix 2	93..119	CDD:320636	11/26 (42%)
		TM helix 3	130..160	CDD:320636	9/29 (31%)
		TM helix 4	172..194	CDD:320636	6/21 (29%)
		TM helix 5	220..249	CDD:320636	8/28 (29%)
		TM helix 6	264..294	CDD:320636	11/134 (8%)
		TM helix 7	302..327	CDD:320636	11/24 (46%)