Protein Alignment CCKLR-17D1 and prlhr2a

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001034615.1
• Gene: prlhr2a / 654782
• ZFINID: ZDB-GENE-060209-1
• Length: 370
• Species: Danio rerio
• Alignment Length: 514
• Identity: 113/514 - (21%)
• Similarity: 180/514 - (35%)
• Gaps: 194/514 - (37%)

  Fly   158 TVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDI 222
            |.|.|....|..:.:..|: ::|||:.::|..|.||.|::..:.|.::|..:||.|:.|||.||:
Zfish    42 TKRNPQFVGVELLQSFKPL-IIPCYALVVLVGVFGNYLLLYVICQTKKMHNVTNFFIGNLAFSDM 105

  Fly   223 LLGVFCMPVTLVGTL-LRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTW 286
            |:...|:|.||.... .|.::||..:|.|:...|..:|.||.:||.||..:||||..|||:.|.
Zfish   106 LMCATCVPFTLAYAFNPRGWVFGRFMCYLVFLIQPVTVYVSVFTLTAIGVDRYYATVHPLKKRI- 169

  Fly   287 QTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQW---PADSLNYERAYN-LFLD 347
             ::.....:::.||:.|...:.|..|.:..:.....|...|.|.|   ..:.|.|  ||: ||:
Zfish   170 -SVLACTYLLSGIWILSCGLVAPAVAHTYHVEFKDEGFTICEEFWMGQEKERLAY--AYSTLFI- 230

  Fly   348 LALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQS 412
              ..||||.||..:||.|:    |.:||                                  |
Zfish   231 --TYVLPLSALCISYLCIS----VKLRN----------------------------------C-- 253

  Fly   413 LDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQING 477
               :||.
Zfish   254 ---VVPG---------------------------------------------------------- 257

  Fly   478 GGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSL 542
                               ||.:.|.:.|:
Zfish   258 -------------------HRTQSQAEAQR----------------------------------- 268

  Fly   543 ESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAY----SSSCCN 603
            ..|::..:::.::|..|.|||.|:.|.|    :|.....:.:.......:|||.:    ||||||
Zfish   269 ARKRKTFRLVSLVVAAFGICWLPISVFN----VLRDIDIDLIDKRYFLLIQLLCHLCGMSSSCCN 329

  Fly   604 PITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSKNETNLSVAGNSIALANSVM 662
            |..|.:::..||.    ..:.|..|.|              ...:.:..|:.|.|:.|:
Zfish   330 PFLYAWLHDRFRA----ELRKMFTCHR--------------RIGIGIPANNCATASVVL 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	101/449 (22%)
		TM helix 1	178..202	CDD:410628	8/23 (35%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	10/23 (43%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	11/28 (39%)
prlhr2a	NP_001034615.1	7tmA_PrRP_R	59..344	CDD:320516	102/455 (22%)
		TM helix 1	60..86	CDD:320516	8/26 (31%)
		TM helix 2	93..118	CDD:320516	13/24 (54%)
		TM helix 3	132..162	CDD:320516	14/29 (48%)
		TM helix 4	173..194	CDD:320516	4/20 (20%)
		TM helix 5	220..249	CDD:320516	15/37 (41%)
		TM helix 6	269..299	CDD:320516	9/33 (27%)
		TM helix 7	312..337	CDD:320516	11/24 (46%)