Protein Alignment CCKLR-17D1 and hcrtr2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001073337.1
• Gene: hcrtr2 / 561260
• ZFINID: ZDB-GENE-070228-3
• Length: 424
• Species: Danio rerio
• Alignment Length: 506
• Identity: 127/506 - (25%)
• Similarity: 198/506 - (39%)
• Gaps: 174/506 - (34%)

  Fly   177 WV-VPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRH 240
            || :..|..:.|.::|||.||...:.:|..|||:||.|::||:.:|||:.:.|:|.:||..:...
Zfish    55 WVLIAGYILVFLVSLVGNTLVCFAVWKNHHMRTVTNYFIVNLSFADILVTITCLPASLVVDITET 119

  Fly   241 FIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLV 305
            :.||:.|||::.:.|..||:||..||..|:.:|:|||||||:.::  |...|.|.|.:|||.|.:
Zfish   120 WFFGQTLCKILPYLQTISVSVSVLTLSCIAQDRWYAICHPLKFKS--TAKRARKSIVLIWLVSCI 182

  Fly   306 CMTPIAAF---SQLMP--TSRPGL-RKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLF 364
            .|.|.|..   |.|||  |::..| ..|.|||| |.: |.:.|:....:.....||..:...|:.
Zfish   183 MMIPQAVVMESSSLMPELTNKTSLFTVCDEQWP-DEI-YPKVYHTCFFIVTYFAPLCLMVLAYIQ 245

  Fly   365 ITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHH 429
            |                                            |..
Zfish   246 I--------------------------------------------CHK----------------- 249

  Fly   430 HSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCS 494
                                         |:|           |||.|....|
Zfish   250 -----------------------------LWC-----------QQIPGSSSVL------------ 262

  Fly   495 RVHRMRQQMQLQQQGY-VSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLE 558
                .||...||...: |...||.:...|..|.           |.|.::::::..:||.|::..
Zfish   263 ----QRQWKSLQCSAHAVGSGESVKVRTSTVSA-----------EAKQVKARRKTARMLMVVLFV 312

  Fly   559 FFICWTPLYVINTMTMLLG--------PTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFR 615
            |.:|:.|:.::|.|..:.|        .|||.:     .:|...|.|::|..|||.|.|::..||
Zfish   313 FALCYLPISILNIMKRVFGAFKNTGNRETVYAW-----FTFSHWLIYANSAANPIIYNFLSGKFR 372

  Fly   616 RAFVDTFKGMRVCERLCAPCCFWR-----RRSKNET------NLSVAGNSI 655
                :.||...:|:      |..|     :|::..|      :||...|::
Zfish   373 ----EEFKAAFICQ------CSGRGETHKQRARGRTSTDSRKSLSTQVNNL 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	117/456 (26%)
		TM helix 1	178..202	CDD:410628	8/24 (33%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	7/15 (47%)
		TM helix 5	340..363	CDD:410628	3/22 (14%)
		TM helix 6	549..571	CDD:410628	6/21 (29%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)
hcrtr2	NP_001073337.1	7tmA_OXR	55..375	CDD:320336	117/460 (25%)
		TM helix 1	56..82	CDD:320336	8/25 (32%)
		TM helix 2	89..115	CDD:320336	12/25 (48%)
		TM helix 3	127..157	CDD:320336	13/29 (45%)
		TM helix 4	168..189	CDD:320336	9/20 (45%)
		TM helix 5	220..249	CDD:320336	6/72 (8%)
		TM helix 6	297..327	CDD:320336	7/29 (24%)
		TM helix 7	343..368	CDD:320336	10/29 (34%)
		Orexin_rec2	390..>424	CDD:427531	5/24 (21%)