Protein Alignment CCKLR-17D1 and sstr2b

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_017210358.2
• Gene: sstr2b / 560530
• ZFINID: ZDB-GENE-130530-727
• Length: 373
• Species: Danio rerio
• Alignment Length: 549
• Identity: 116/549 - (21%)
• Similarity: 195/549 - (35%)
• Gaps: 208/549 - (37%)

  Fly   124 NYSGLELDLGLDLDLNLDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLC 188
            |.||..|..|| |:::.:...:..|....        |..|.:||.|          .|..:.:.
Zfish    16 NLSGYSLYDGL-LNISEEETQSNEPEQHL--------TNTNTAVVTV----------MYFLVCVV 61

  Fly   189 AVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQF 253
            .:.||.||:..:::..:|:|:||:::||||::|||. :..:|...:...:.|:.||..:|.::..
Zfish    62 GLCGNALVIYVILRYAKMKTVTNIYILNLAVADILF-MLSLPFIAIQLAMVHWPFGATMCHVVIT 125

  Fly   254 AQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMP 318
            ..:.:...|.:.|:.:|.:||.|:.||::|..|:....|......:|:.||:.:.|:..:|.|:
Zfish   126 IDSLNQFTSIFCLMVMSIDRYLAVVHPMKSIKWRKPQVAKATNVAVWVVSLLVILPVVFYSGLI- 189

  Fly   319 TSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGS 383
            |...|. .|...||.....|:.|:.::..|....|||:.:...||.|            .:...|
Zfish   190 TKAEGC-FCSIVWPDPQGAYQTAFMIYTFLLGFFLPLMVICLCYLLI------------IIKVKS 241

  Fly   384 SGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLIS 448
            ||.:|::                                                   ||||.
Zfish   242 SGIKVSS---------------------------------------------------SKRRY-- 253

  Fly   449 GGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSD 513
                                                                             
Zfish   254 ----------------------------------------------------------------- 253

  Fly   514 NESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGP 578
                                          |:|:|.:::.|:||.|..||.|.|:.| ||.:.|
Zfish   254 ------------------------------SEKKVTRLVSVVVLVFVFCWLPFYIFN-MTSVTG- 286

  Fly   579 TVYEYVGYTSI-SFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRS 642
            |:.:.....|: :|:.:|.|::||.|||.|.|::.:||::|.:..             ||
Zfish   287 TISDTPFLRSVFAFVVVLGYANSCANPILYAFLSENFRKSFQNVL-------------CF----- 333

  Fly   643 KNETNLSVAGNSIALANSVMSSHTILESP 671
            |.|. ||.|..|    ||.:....||..|
Zfish   334 KKEA-LSDAARS----NSRLDRPQILNDP 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	89/441 (20%)
		TM helix 1	178..202	CDD:410628	5/23 (22%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	2/21 (10%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	11/25 (44%)
sstr2b	XP_017210358.2	None