Protein Alignment CCKLR-17D1 and NPY4R

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 108/474 - (22%)
• Similarity: 169/474 - (35%)
• Gaps: 186/474 - (39%)

  Fly   161 TPGNRSV-VRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILL 224
            ||.|.|. .:.|.||.:::|..||...:..|:|||.::...|:.:....:||:.:.|||.||.|:
Human    26 TPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLM 90

  Fly   225 GVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQ-T 288
            .:.|.|:|.|.|::.::||||.|||:..|.|..||.||..:||.::.||:..|.:|   ..|: :
Human    91 CLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINP---TGWKPS 152

  Fly   289 INHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRK----------CREQWPADSLNYERAYN 343
            |:.|...|.:||:.:.|...|..|.|.|.........|          |.|.||.  .::...|.
Human   153 ISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPL--AHHRTIYT 215

  Fly   344 LFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGS 408
            .||.|....|||     .::.:
Human   216 TFLLLFQYCLPL-----GFILV------------------------------------------- 232

  Fly   409 HCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQ 473
                                                                             
Human   233 ----------------------------------------------------------------- 232

  Fly   474 QINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNE 538
                              |.:|::|.     ||:||                 |:...|
Human   233 ------------------CYARIYRC-----LQRQG-----------------RVFHKG------ 251

  Fly   539 TKSLES--KKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVG--YTSISFL--QLLAY 597
            |.||.:  .|:|..:|.|:|:.|.:.|.||:|.|:    |....:|.:.  :.::.||  .|||.
Human   252 TYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNS----LEDWHHEAIPICHGNLIFLVCHLLAM 312

  Fly   598 SSSCCNPITYCFMNASFRR 616
            :|:|.||..|.|:|.:|::
Human   313 ASTCVNPFIYGFLNTNFKK 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	101/457 (22%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	4/15 (27%)
		TM helix 5	340..363	CDD:410628	7/22 (32%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	11/26 (42%)
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	101/458 (22%)
		TM helix 1	43..69	CDD:320519	8/25 (32%)
		TM helix 2	76..101	CDD:320519	11/24 (46%)
		TM helix 3	114..144	CDD:320519	12/29 (41%)
		TM helix 4	155..176	CDD:320519	6/20 (30%)
		TM helix 5	211..240	CDD:320519	9/159 (6%)
		TM helix 6	258..288	CDD:320519	11/33 (33%)
		TM helix 7	301..326	CDD:320519	11/24 (46%)