Protein Alignment CCKLR-17D1 and Ednrb

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_059029.1
• Gene: Ednrb / 50672
• RGDID: 2536
• Length: 442
• Species: Rattus norvegicus
• Alignment Length: 566
• Identity: 108/566 - (19%)
• Similarity: 174/566 - (30%)
• Gaps: 253/566 - (44%)

  Fly   147 TPSSSTLAPAVTVRTP---------GNRSVVRVSADVPI-------------WVVPC-------- 181
            |||   |.....|.||         .|.|::|.||...:             :..||
  Rat    37 TPS---LLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINK 98

  Fly   182 ----YSAILLC-----AVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTL 237
                .:.|:.|     .::||..::..:.:|:.||...|:.:.:||:.|:|..:..:|:.....|
  Rat    99 TFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLL 163

  Fly   238 LRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSR-----TWQTINHANKIIA 297
            ...:.||..:|||:.|.|.|||.::..:|.|:|.:||.|:....|.:     .|..:.     |.
  Rat   164 AGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVE-----IV 223

  Fly   298 IIWLGSLVCMTPIAAFSQLMPTSRPG--LRKCREQWPADSLN----------YERAYNLFLDLAL 350
            :||:.|:|...|.|....::.:...|  ||.|       .||          |:.|.:.:|....
  Rat   224 LIWVVSVVLAVPEAIGFDVITSDYKGKPLRVC-------MLNPFQKTAFMQFYKTAKDWWLFSFY 281

  Fly   351 LVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDT 415
            ..|||...:..|..:|                                           |:.|
  Rat   282 FCLPLAITAIFYTLMT-------------------------------------------CEML-- 301

  Fly   416 IVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGG 480
                                                                             
  Rat   302 ----------------------------------------------------------------- 301

  Fly   481 TLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESK 545
                                                |:||..|.:|            ...|:.:
  Rat   302 ------------------------------------RKKSGMQIAL------------NDHLKQR 318

  Fly   546 KRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVG---YTSISFLQLLAY-------SSS 600
            :.|.|.:|.|||.|.:||.||:    ::.:|..|:|:...   ...:|||.:|.|       .:|
  Rat   319 REVAKTVFCLVLVFALCWLPLH----LSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNS 379

  Fly   601 CCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPC-CFWRRRSKNE 645
            |.|||....::..|:..|       :.|  ||..| .|..::|..|
  Rat   380 CINPIALYLVSKRFKNCF-------KSC--LCCWCQTFEEKQSLEE 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	88/484 (18%)
		TM helix 1	178..202	CDD:410628	6/40 (15%)
		TM helix 2	211..233	CDD:410628	6/21 (29%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	10/21 (48%)
		TM helix 7	586..611	CDD:410628	10/31 (32%)
Ednrb	NP_059029.1	7tmA_ET-BR	102..397	CDD:320642	86/468 (18%)
		TM helix 1	103..129	CDD:320642	4/25 (16%)
		TM helix 2	136..162	CDD:320642	6/25 (24%)
		TM helix 3	174..204	CDD:320642	14/29 (48%)
		TM helix 4	216..236	CDD:320642	6/24 (25%)
		TM helix 5	270..295	CDD:320642	6/24 (25%)
		TM helix 6	316..346	CDD:320642	11/33 (33%)
		TM helix 7	365..390	CDD:320642	7/24 (29%)